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Newly released emails bring Trump's relationship with Epstein back into spotlight

admin - Latest News - November 13, 2025
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The relationship between President Donald Trump and convicted sex offender Jeffrey Epstein has come into the spotlight again after House Democrats released emails in which Epstein claims Trump “knew about the girls.” In a statement to NBC News, White House press secretary Karoline Leavitt accused Democrats of “selectively leaked emails to the liberal media to create a fake narrative to smear President Trump.” NBC News’ Hallie Jackson reports. 



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October 9, 2025
Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleOct. 9, 2025, 3:53 PM EDTBy Kate Reilly and Saba HamedyJimmy Kimmel pressed comedian Aziz Ansari this week about his decision to perform at Saudi Arabia’s Riyadh Comedy Festival, with Kimmel calling the Saudi government a “pretty brutal regime” and questioning why Ansari would “take their money.”Held in Saudi Arabia’s capital city, the Riyadh Comedy Festival began on Sept. 26 and ends Thursday. The event has hosted over 50 stand-up comedians from around the world, including big names such as Ansari, Kevin Hart, Pete Davidson and Dave Chappelle. Those comedians have been facing backlash since accepting seemingly lucrative deals to perform in a country that has been criticized for its human rights violations.In an interview on “Jimmy Kimmel Live!” on Tuesday night, Kimmel pressed Ansari about his decision to take the stage in Riyadh. “People, a lot of comedians especially, are very upset, because the people who paid the comedians to come to this are not good people,” Kimmel said. “It’s a pretty brutal regime. They’ve done a lot of horrible, horrible things.” The talk show host then asked Ansari why he chose to appear at the event, stating that “people are questioning why you would go over there and take their money to perform in front of these people.”Ansari said he put a lot of thought into the decision, explaining that he consulted his aunt, who used to live in Saudi Arabia.”There’s people over there that don’t agree with the stuff that the government’s doing, and to ascribe like the worst behavior of the government onto those people, that’s not fair,” Ansari said his aunt pointed out. “Just like there’s people in America that don’t agree with the things the government is doing.”Kimmel agreed that “we’re doing horrible things over here,” but pushed back on Ansari’s comparison between the U.S. and Saudi Arabia. “They murdered a journalist,” Kimmel said, referring to Washington Post columnist Jamal Khashoggi, who was killed at the Saudi Consulate in Istanbul in 2018. Kimmel then asked Ansari if he had dealt “with those people specifically.”Ansari replied, “No, I was just there to do a show for the people.” The comedian further explained his thought process, saying his wife told him that “whenever there’s repressive societies like this, they try to keep things out — whether it’s rock ‘n’ roll music or blue jeans — because it makes people curious about outside ideas, outside values.”Ansari, who is Indian American, went on to add that “to me, a comedy festival felt like something that’s pushing things to be more open and to push a dialogue.” He then discussed how his own background compelled him to do the performance.”For me, especially being me and looking the way I do and being from a Muslim background, it felt like something I should be a part of. And I hope it pushes things in a positive direction.”Ansari did not immediately respond to an NBC News request for comment. When speaking to Bloomberg’s Lucas Shaw at the publication’s Screentime event on Wednesday, Kimmel — whose show recently returned to the air after it was briefly suspended by ABC and Disney over the host’s remarks about Charlie Kirk’s assassination — addressed why he pressed Ansari on the matter.“I wouldn’t have gone (to Riyadh), but I wanted to hear his reasons,” said Kimmel, who also noted that Ansari was aware he would ask him about the festival.“Nothing’s black and white,” Kimmel added. “It’s not something I would do, but I do understand the idea that if we close ourselves off to the world … maybe that’s not good. I don’t know that my reasoning is correct reasoning.”He drew a parallel to current U.S. politics. “We see it happening in this country, too,” he said. “We travel abroad, many of us don’t want to be held accountable for what our president does and says.” Kimmel’s skepticism about the Riyadh Comedy Festival comes after many comedians have publicly criticized the event.”WFT” podcast host Marc Maron ripped into the festival in a stand-up clip posted to Instagram on Sept. 23. “I mean, how do you even promote that?” Maron said. “Like, ‘From the folks that brought you 9/11, two weeks of laughter in the desert. Don’t miss it.’”Shane Gillis also condemned the event on his podcast, and said that the festival organizers “doubled the bag” after he declined to perform. Human Rights Watch wrote in a press release published on Sept. 23 that the Saudi government is using the comedy festival “to deflect attention from its brutal repression of free speech and other pervasive human rights violations.”The Saudi Embassy in Washington, D.C., and Saudi Arabia’s General Entertainment Authority, which announced the festival in July, did not immediately respond to requests for comment.Kate ReillyKate Reilly is a news associate with NBC News.Saba HamedySaba Hamedy is the trends and culture editor for NBC News.
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Nov. 27, 2025, 6:00 AM ESTBy Akshay Syal, M.D.For decades, doctors have been puzzled by why women develop Alzheimer’s disease at nearly twice the rate of men. There are an estimated 7 million people in the U.S. living with Alzheimer’s, with that number expected to reach nearly 13 million by 2050. A majority of cases, or about 2 out of every 3, are in women. An emerging body of research is suggesting that estrogen, the predominant female sex hormone, may play a critical role, specifically in the perimenopausal transition to menopause, when the body’s hormone levels naturally begin to decline. Estrogen is thought to perform a variety of functions in the body, such as improving cardiovascular health and maintaining bone density. Estrogen is very important to the brain and is considered neuroprotective, helping shield brain cells from inflammation, stress and other forms of cellular damage. Alzheimer’s researchers are focused on the early period of perimenopause, which typically occurs in a woman’s early- to mid-40s, as a target for hormone replacement therapy to maintain estrogen levels and possibly protect some women against developing dementia decades later. “This interest comes primarily from decades of pre-clinical research, animal models, and basic science research showing that menopause is a tipping point for Alzheimer’s pathology,” said Lisa Mosconi, director of the Alzheimer’s Prevention Program at Weill Cornell Medicine. Mosconi is leading a new $50 million global women’s health research initiative called CARE, or Cutting women’s Alzheimer’s risk through endocrinology. Looking at biomarkers from nearly 100 million women, it’s expected to be the largest analysis of why women are at greater risk of Alzheimer’s disease. The link between estrogen and dementia has gained renewed focus after the Food and Drug Administration recently lifted the decades-old black-box warning on hormone replacement therapy, a move that may lead to many more women in their 40s and 50s being prescribed treatment. Doctors say loosened restrictions could reduce stigma around hormone therapy. The FDA’s move could also pave the way for broader research into whether hormone replacement therapy might offer additional benefits, including protection against dementia. Declining reproductive hormonesMenopause occurs when the ovaries gradually produce less estrogen and progesterone, hormones that help regulate the menstrual cycle. Estrogen and progesterone are sex hormones that are present in females and to a lesser extent in males that play an important role in sexual and reproductive development. Most women reach menopause between the ages of 45 and 55, said Dr. Monica Christmas, a gynecologist and director of the menopause program at UChicago Medicine. The transition can begin years earlier during perimenopause, which usually starts when women are in their mid-40s. That’s when symptoms such as hot flashes, night sweats, mood changes and sleep disturbances often appear. It’s thought that menopause symptoms are caused by decreased levels of estrogen and progesterone in the body. For example, when estrogen levels drop, the body’s internal thermostat, controlled by the hypothalamus in the brain, begins to not work properly. The brain might interpret the body as too hot and tell it to start sweating to cool off, leading to symptoms of hot flashes. Hormone therapy can replenish those levels and help the body regulate its temperature. What role does estrogen play?Receptors for this sex hormone are found throughout our brains, said Rachel Buckley, an associate professor of neurology at Massachusetts General Hospital whose research focuses on sex differences in Alzheimer’s disease. “Estrogen is actually a really powerful hormone,” she said. “It’s found in the hippocampus which is an area [in the brain] that we know is very closely associated with memory and learning.” Estrogen also helps to build and maintain healthy blood flow in the brain, she added, and can even help the brain use energy more efficiently. During menopause, however, the levels of estrogen begin to decline, potentially leaving the brain more vulnerable to damage. “Once the brain loses the protective effects of estrogen and other sex hormones, it’s a turning point for Alzheimer’s pathology accumulation in the brain,” said Mosconi. Can hormone replacement therapy fight dementia?Hormone replacement therapy is available in many forms, including a wearable patch, cream and pills, and can include either estrogen, progesterone, or both. If estrogen helps protect our brain, it would make sense that replacing levels through hormone therapy might confer some sort of benefit. It turns out, however, the answer is much more complicated than that, experts say, as the research behind hormone replacement therapy is mixed and ongoing.However, data suggests that the perimenopause transition might represent a critical window of opportunity where treatment could help some patients ward off dementia, said Dr. Kellyann Niotis, a preventive neurologist in Florida and faculty member at Weill Cornell Medicine. “One leading belief is that during this perimenopausal window hormones are fluctuating rapidly and you can have steep declines in [estrogen] which can be harmful for the brain,” said Niotis.“The idea is that using hormones at a steady state or consistent level kind of helps even out those fluctuations.” A large analysis from Mosconi and her team in 2023 published in Frontiers in Aging Neuroscience found that there may be a sweet spot for initiation of HRT for helping women fight cognitive decline.Her team analyzed over 50 studies and found that people using estrogen therapy in midlife, or within 10 years of their final menstrual period, had a significantly lower risk of dementia. Conversely, when combination hormone therapy was initiated after 65, there was an increased risk of dementia. Another large-scale analysis of 50 studies presented this fall at the American Neurological Association annual meeting found that the risk of Alzheimer’s was up to 32% lower among women who started HRT within five years of menopause than in those who received a placebo or no treatment. The paper is not yet peer-reviewed or published in a journal. The research, which was done by scientists based in India, also found that among women who waited until they were 65 or older to start therapy, there was a 38% increase in Alzheimer’s risk. However, many of the studies performed to date have been observational, said Christmas, and do not directly prove a cause and effect relationship. More rigorous research including large scale trials are needed, she added. Hormone therapy that is prescribed may also not behave exactly like estrogen that is produced naturally by the body, she added, and also requires further study.Why timing of hormone therapy mattersThe theory of a critical window to initiate hormone replacement therapy may be related to estrogen receptors in the brain, said Mosconi. During the transition to menopause, there becomes a progressively higher density of estrogen receptors on brain cells, her research has found. This is because, as estrogen levels naturally decline, the brain increases the amount of available receptors as a compensatory mechanism to try and grab every little bit of estrogen that’s still available to be used up, she said. But at some point, when estrogen is permanently low, the brain ultimately stops trying and gives up, and the estrogen receptors disappear, she added. “That is the end of the window of opportunity because once the estrogen receptors are gone, there’s no point putting estrogen back in the system because it has nothing to bind to,” said Mosconi.Some outstanding questions remain, including how long women would need to stay on hormone replacement therapy or whether estrogen would be more protective for women with a genetic predisposition to Alzheimer’s. It’s also unclear if the brain responds differently to estrogen the body makes compared to hormone replacement. Men, on the other hand, have biologically different brains than women, said Buckley, as they have significantly less estrogen receptors and thus have a lower requirement of the hormone. It’s also unclear if testosterone replacement therapy for men confer any potential benefit for Alzheimer’s prevention, said Niotis. While some studies have suggested an association between men with lower testosterone and dementia, much more research is needed before any definitive conclusions can be made. Experts say it’s still too early to recommend hormone replacement therapy to prevent Alzheimer’s disease.“We do not use hormone therapy for Alzheimer’s prevention right now,” said Mosconi. “Clinical guidelines currently do not endorse using hormone therapy only for Alzheimer’s prevention.” Instead, HRT should be prescribed primarily to treat moderate to severe menopausal symptoms that can affect quality of life, such as hot flashes, night sweats, sleep disturbances or mood changes. Niotis said relieving these symptoms may help improve cognition, as people who sleep better have improved mood and tend to think more clearly. Still, she is optimistic that future research may bring more definitive answers. “The hope is that with the removal of this black-box warning that we’ll have more women that are starting therapies and are less afraid of using them, and more doctors that are less afraid of prescribing them,” said Niotis. Akshay Syal, M.D.Dr. Akshay Syal is a board-certified internal medicine physician at UCLA Health and instructor of medicine at the David Geffen School of Medicine at UCLA. He also is a member of the NBC News Health Unit, reporting for both NBC News Digital and on air for NBC News NOW and MSNBC.  
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