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admin - Latest News - November 25, 2025
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Nov. 25, 2025, 6:40 AM ESTBy Evan BushAs we age, the human brain rewires itself. The process happens in distinct phases, or “epochs,” according to new research, as the structure of our neural networks changes and our brains reconfigure how we think and process information.For the first time, scientists say they’ve identified four distinct turning points between those phases in an average brain: at ages 9, 32, 66 and 83. During each epoch between those years, our brains show markedly different characteristics in brain architecture, they say.The findings, published Tuesday in the journal Nature Communications, suggest that human cognition does not simply increase with age until a peak, then decline. In fact, the phase from ages 9 to 32 is the only time in life when our neural networks are becoming increasingly efficient, according to the research. During the adulthood phase, from 32 to 66, the average person’s brain architecture essentially stabilizes without major changes, at a time when researchers think people are generally plateauing in intelligence and personality. And in the years after the last turning point — 83 and beyond — the brain becomes increasingly reliant on individual regions as connections between them begin to wither away. “It’s not a linear progression,” said Alexa Mousley, a postdoctoral researcher associate at the University of Cambridge, who is the study’s lead author. “This is the first step of understanding the way the brain’s changing fluctuates based on age.” How AI is transforming healthcare across the country03:59The findings could help identify why mental health and neurological conditions develop during particular phases of rewiring.Rick Betzel, a professor of neuroscience at the University of Minnesota who was not involved in the research, said the findings are intriguing, but more data is needed to support the conclusions. The theories may not hold up to scrutiny over time, he said.“They did this really ambitious thing,” Betzel said of the study. “Let’s see where it stands in a few years.” For their research, Mousley and her colleagues analyzed MRI diffusion scans — which are essentially images of how water molecules move within the brain — from about 3,800 people from age 0 to age 90. The goal was to map the neural connections across the average person’s brain at different stages in life. In the brain, the bundles of nerve fibers that transfer signals are encapsulated in fatty tissue called myelin. Think of it like wiring or plumbing. Water molecules diffused in the brain tend to move in the direction of these fibers, rather than across them, meaning researchers can infer where the neural pathways are located. “We can’t crack open skulls … we rely on non-invasive approaches,” Betzel said of this type of neuroscience research. “What we’re trying to figure out is where these fiber bundles are at.” Based on the MRI scans, the new study maps the neural network of an average person across a lifespan, determining where connections are strengthening or weakening. The five “epochs” it describes are based on the neural connections the researchers observed. The first phase is from 0 to age 9, they suggest. The brain rapidly increases in gray and white matter; it prunes extra synapses and restructures itself. From ages 9 to 32, there is an extended period of rewiring. The brain is defined by rapid communication across the entire brain and efficient connections between different regions. Most mental health disorders are diagnosed during this time period, Mousely said: “Is there something about this second era of life, as we find it, that could lead people to be more vulnerable to the onset of mental health disorders?”From 32 to 66, the brain plateaus. It’s still rewiring itself, but less dramatically and more slowly. Then, from 66 to age of 83, the brain tends toward “modularity,” where the neural network is divided into highly connected subnetworks with less central integration. At age 83, connectivity declines further. Betzel said the theory described in the study likely jives with people’s lived experiences with aging and cognition. “It’s intuitively something we gravitate towards. I have two kids and they’re really young. I think all of the time, ‘I’m getting out of my toddler era,’” Betzel said. “Maybe the science ends up being there. But are those the exact right ages? I don’t know.” In the ideal version of a study like this, he added, the researchers would have MRI diffusion data for a large group of people, each of whom were scanned during every year of life from birth to death. But that wasn’t possible because the technology wasn’t available decades ago. Instead, the researchers combined nine different data sets containing neuroimaging from previous studies and attempted to harmonize them. Betzel said each of those data sets varies in quality and approach, and the effort to make them correspond with one another could wash away important variability, ultimately leading to bias in the results. Nonetheless, he said the authors of the paper are “thoughtful” and skilled scientists who did their best to control for that possibility. “Brain networks change over the lifespan — absolutely. Is it discrete such that there are five exact change points? I’d say stay tuned. It’s an interesting idea.”Evan BushEvan Bush is a science reporter for NBC News.
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By Katherine DoylePresident Donald Trump has directed the federal agency that oversees legal immigration to the U.S. conduct a sweeping review of Green Card holders from what the administration calls countries of concern, the head of U.S. Citizenship and Immigration Services said Thursday.“At the direction of @POTUS, I have directed a full scale, rigorous reexamination of every Green Card for every alien from every country of concern,” USCIS Director Joseph Edlow said Thursday afternoon in a statement on X.Edlow said that protecting the country “remains paramount” and that “the American people will not bear the cost of the prior administration’s reckless resettlement policies.”USCIS did not immediately respond to a request for details on which countries are considered “of concern.”The U.S. Citizenship and Immigration Services Miami Field Office.Wilfredo Lee / APThe move comes a day after a shooting near the White House left two members of the National Guard in critical condition. Federal prosecutors say the suspect, an Afghan national who once assisted American forces, was resettled in the U.S. under a program called Operation Allies Welcome during the Biden administration following the U.S. withdrawal from Afghanistan in 2021.Jeanine Pirro, the U.S. Attorney for the District of Columbia, said Thursday morning that her office is reviewing the suspect’s immigration history and the vetting process that allowed his entry into the country.A source familiar with the case and a separate law enforcement source told NBC News that the suspect was granted asylum this year.D.C. National Guard shooting suspect faces charges of assault with intent to kill02:25Two West Virginia National Guard members — identified as Sarah Beckstrom, 20, and Andrew Wolfe, 24, from West Virginia — remain in critical condition following the attack. They were in Washington as part of Trump’s deployment of federal troops to several U.S. cities.In a video released by the White House, Trump called the attack an “act of terror” and said additional National Guard troops would be deployed to Washington.The administration said all immigration requests relating to Afghan nationals will be halted indefinitely.This is a developing story. Please check back for updates.Katherine DoyleKatherine Doyle is a White House reporter for NBC News.
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