• Police seek suspects in deadly birthday party shooting
  • Lawmakers launch inquires into U.S. boat strike
  • Nov. 29, 2025, 10:07 PM EST / Updated Nov. 30, 2025,…
  • Mark Kelly says troops ‘can tell’ what orders…

Be that!

contact@bethat.ne.com

 

Be That ! Menu   ≡ ╳
  • Home
  • Travel
  • Culture
  • Lifestyle
  • Sport
  • Contact Us
  • Politics Politics
☰

Be that!

Jimmy Kimmel suspension might have been a factor in shooting at Sacramento ABC affiliate, DA says

admin - Latest News - September 22, 2025
admin
34 views 17 secs 0 Comments




The man accused of opening fire on an ABC affiliate in Sacramento last week might’ve been motivated in part by that network’s suspension of late-night host Jimmy Kimmel, authorities said Monday



Source link

TAGS:
PREVIOUS
Supreme Court takes up dispute over Trump's authority to fire FTC member
NEXT
Zohran Mamdani pulls out of local ABC town hall over Jimmy Kimmel suspension
Related Post
November 27, 2025
Nov. 27, 2025, 6:00 AM ESTBy Akshay Syal, M.D.For decades, doctors have been puzzled by why women develop Alzheimer’s disease at nearly twice the rate of men. There are an estimated 7 million people in the U.S. living with Alzheimer’s, with that number expected to reach nearly 13 million by 2050. A majority of cases, or about 2 out of every 3, are in women. An emerging body of research is suggesting that estrogen, the predominant female sex hormone, may play a critical role, specifically in the perimenopausal transition to menopause, when the body’s hormone levels naturally begin to decline. Estrogen is thought to perform a variety of functions in the body, such as improving cardiovascular health and maintaining bone density. Estrogen is very important to the brain and is considered neuroprotective, helping shield brain cells from inflammation, stress and other forms of cellular damage. Alzheimer’s researchers are focused on the early period of perimenopause, which typically occurs in a woman’s early- to mid-40s, as a target for hormone replacement therapy to maintain estrogen levels and possibly protect some women against developing dementia decades later. “This interest comes primarily from decades of pre-clinical research, animal models, and basic science research showing that menopause is a tipping point for Alzheimer’s pathology,” said Lisa Mosconi, director of the Alzheimer’s Prevention Program at Weill Cornell Medicine. Mosconi is leading a new $50 million global women’s health research initiative called CARE, or Cutting women’s Alzheimer’s risk through endocrinology. Looking at biomarkers from nearly 100 million women, it’s expected to be the largest analysis of why women are at greater risk of Alzheimer’s disease. The link between estrogen and dementia has gained renewed focus after the Food and Drug Administration recently lifted the decades-old black-box warning on hormone replacement therapy, a move that may lead to many more women in their 40s and 50s being prescribed treatment. Doctors say loosened restrictions could reduce stigma around hormone therapy. The FDA’s move could also pave the way for broader research into whether hormone replacement therapy might offer additional benefits, including protection against dementia. Declining reproductive hormonesMenopause occurs when the ovaries gradually produce less estrogen and progesterone, hormones that help regulate the menstrual cycle. Estrogen and progesterone are sex hormones that are present in females and to a lesser extent in males that play an important role in sexual and reproductive development. Most women reach menopause between the ages of 45 and 55, said Dr. Monica Christmas, a gynecologist and director of the menopause program at UChicago Medicine. The transition can begin years earlier during perimenopause, which usually starts when women are in their mid-40s. That’s when symptoms such as hot flashes, night sweats, mood changes and sleep disturbances often appear. It’s thought that menopause symptoms are caused by decreased levels of estrogen and progesterone in the body. For example, when estrogen levels drop, the body’s internal thermostat, controlled by the hypothalamus in the brain, begins to not work properly. The brain might interpret the body as too hot and tell it to start sweating to cool off, leading to symptoms of hot flashes. Hormone therapy can replenish those levels and help the body regulate its temperature. What role does estrogen play?Receptors for this sex hormone are found throughout our brains, said Rachel Buckley, an associate professor of neurology at Massachusetts General Hospital whose research focuses on sex differences in Alzheimer’s disease. “Estrogen is actually a really powerful hormone,” she said. “It’s found in the hippocampus which is an area [in the brain] that we know is very closely associated with memory and learning.” Estrogen also helps to build and maintain healthy blood flow in the brain, she added, and can even help the brain use energy more efficiently. During menopause, however, the levels of estrogen begin to decline, potentially leaving the brain more vulnerable to damage. “Once the brain loses the protective effects of estrogen and other sex hormones, it’s a turning point for Alzheimer’s pathology accumulation in the brain,” said Mosconi. Can hormone replacement therapy fight dementia?Hormone replacement therapy is available in many forms, including a wearable patch, cream and pills, and can include either estrogen, progesterone, or both. If estrogen helps protect our brain, it would make sense that replacing levels through hormone therapy might confer some sort of benefit. It turns out, however, the answer is much more complicated than that, experts say, as the research behind hormone replacement therapy is mixed and ongoing.However, data suggests that the perimenopause transition might represent a critical window of opportunity where treatment could help some patients ward off dementia, said Dr. Kellyann Niotis, a preventive neurologist in Florida and faculty member at Weill Cornell Medicine. “One leading belief is that during this perimenopausal window hormones are fluctuating rapidly and you can have steep declines in [estrogen] which can be harmful for the brain,” said Niotis.“The idea is that using hormones at a steady state or consistent level kind of helps even out those fluctuations.” A large analysis from Mosconi and her team in 2023 published in Frontiers in Aging Neuroscience found that there may be a sweet spot for initiation of HRT for helping women fight cognitive decline.Her team analyzed over 50 studies and found that people using estrogen therapy in midlife, or within 10 years of their final menstrual period, had a significantly lower risk of dementia. Conversely, when combination hormone therapy was initiated after 65, there was an increased risk of dementia. Another large-scale analysis of 50 studies presented this fall at the American Neurological Association annual meeting found that the risk of Alzheimer’s was up to 32% lower among women who started HRT within five years of menopause than in those who received a placebo or no treatment. The paper is not yet peer-reviewed or published in a journal. The research, which was done by scientists based in India, also found that among women who waited until they were 65 or older to start therapy, there was a 38% increase in Alzheimer’s risk. However, many of the studies performed to date have been observational, said Christmas, and do not directly prove a cause and effect relationship. More rigorous research including large scale trials are needed, she added. Hormone therapy that is prescribed may also not behave exactly like estrogen that is produced naturally by the body, she added, and also requires further study.Why timing of hormone therapy mattersThe theory of a critical window to initiate hormone replacement therapy may be related to estrogen receptors in the brain, said Mosconi. During the transition to menopause, there becomes a progressively higher density of estrogen receptors on brain cells, her research has found. This is because, as estrogen levels naturally decline, the brain increases the amount of available receptors as a compensatory mechanism to try and grab every little bit of estrogen that’s still available to be used up, she said. But at some point, when estrogen is permanently low, the brain ultimately stops trying and gives up, and the estrogen receptors disappear, she added. “That is the end of the window of opportunity because once the estrogen receptors are gone, there’s no point putting estrogen back in the system because it has nothing to bind to,” said Mosconi.Some outstanding questions remain, including how long women would need to stay on hormone replacement therapy or whether estrogen would be more protective for women with a genetic predisposition to Alzheimer’s. It’s also unclear if the brain responds differently to estrogen the body makes compared to hormone replacement. Men, on the other hand, have biologically different brains than women, said Buckley, as they have significantly less estrogen receptors and thus have a lower requirement of the hormone. It’s also unclear if testosterone replacement therapy for men confer any potential benefit for Alzheimer’s prevention, said Niotis. While some studies have suggested an association between men with lower testosterone and dementia, much more research is needed before any definitive conclusions can be made. Experts say it’s still too early to recommend hormone replacement therapy to prevent Alzheimer’s disease.“We do not use hormone therapy for Alzheimer’s prevention right now,” said Mosconi. “Clinical guidelines currently do not endorse using hormone therapy only for Alzheimer’s prevention.” Instead, HRT should be prescribed primarily to treat moderate to severe menopausal symptoms that can affect quality of life, such as hot flashes, night sweats, sleep disturbances or mood changes. Niotis said relieving these symptoms may help improve cognition, as people who sleep better have improved mood and tend to think more clearly. Still, she is optimistic that future research may bring more definitive answers. “The hope is that with the removal of this black-box warning that we’ll have more women that are starting therapies and are less afraid of using them, and more doctors that are less afraid of prescribing them,” said Niotis. Akshay Syal, M.D.Dr. Akshay Syal is a board-certified internal medicine physician at UCLA Health and instructor of medicine at the David Geffen School of Medicine at UCLA. He also is a member of the NBC News Health Unit, reporting for both NBC News Digital and on air for NBC News NOW and MSNBC.  
October 31, 2025
Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleOct. 31, 2025, 12:53 PM EDTBy Sahil Kapur, Ryan Nobles and Brennan LeachWASHINGTON — President Donald Trump is pushing Senate Republicans to abolish the 60-vote filibuster rule in order to reopen the shuttered government without Democratic votes.But in a rarity for the president, he’s hitting firm and immediate resistance from his own party.“It is now time for the Republicans to play their ‘TRUMP CARD,’ and go for what is called the Nuclear Option — Get rid of the Filibuster, and get rid of it, NOW!” he wrote in a pair of late-night social media posts Thursday. “Well, now WE are in power, and if we did what we should be doing, it would IMMEDIATELY end this ridiculous, Country destroying ‘SHUT DOWN.’”Senate Republican leaders have been outspoken in their support for the 60-vote rule to pass most bills. The new Majority Leader, John Thune, R-S.D., promised shortly after the 2024 election that the legislative filibuster would remain unchanged on his watch.“Leader Thune’s position on the importance of the legislative filibuster is unchanged,” Thune spokesman Ryan Wrasse said Friday.A spokesperson for Senate Majority Whip John Barrasso, R-Wyo., said: “Senator Barrasso’s support of the filibuster is unchanged.”Yet the conversation about the filibuster escalated on Capitol Hill even before Trump’s comments after Sen. Bernie Moreno, R-Ohio, appeared on Fox News days into the shutdown and called on his party to eliminate the filibuster.But various Republicans have voiced opposition to that push, including Moreno’s fellow Ohio senator.“That’s not a step I think we should take,” Sen. Jon Husted, R-Ohio, told reporters.Sen. Thom Tillis, R-N.C., who has said he would resign from the Senate on the same day if Republicans abolish the filibuster, said he doesn’t expect it to be nixed. He noted that Trump also called on the GOP to eliminate the 60-vote threshold during his first presidential term in order to pass his agenda.“We stood firm there,” Tillis said earlier this month. “I can’t imagine anybody changing now.”Sen. Roger Marshall, R-Kansas, said he “would not be” in favor of weakening the legislative filibuster to pass the funding bill.”That’s a nonstarter,” he said.Sen. Markwayne Mullin, R-Okla., said he would “absolutely not” favor abolishing the filibuster.”If we want to do something very, extremely limited” to “avoid shutdowns in the future, I may consider that,” he said.” But to nuke, to go nuclear into the filibuster — we all know that the Senate goes back and forth, and it’s in our favor when we have the minority.”The Senate, under the control of both parties, has eliminated the 60-vote threshold to confirm executive branch personnel and federal judges; those require a simple majority of the Senate.The legislative filibuster has evolved over the years, but since 1975, it has required 60 votes to achieve “cloture” in the Senate and ensure passage of most bills over the minority’s objections. There are exceptions, such as the budget “reconciliation” process that Republicans used to pass Trump’s “big, beautiful bill.” GOP senators have expanded those exceptions this year, but they’ve largely been opposed to fully removing the 60-vote threshold.That’s because they worry about what a future Democratic-controlled Washington would be able to do without requiring Republican support for legislation.“The 60 vote threshold has protected this country, and frankly, that’s what I think this last election was largely about,” Thune told reporters on Oct. 10, positing that if Democrats had won, they would have sought to get rid of the filibuster, make D.C. and Puerto Rico states with representation in Congress and expand the Supreme Court. “You’d have abortion on demand, a whole bunch of things that were on that laundry list,” he said. “There’s always pressure on the filibuster,” the majority leader said. “But I can tell you that the filibuster through the years has been something that’s been a bulwark against a lot of really bad things happening to the country.”House Speaker Mike Johnson, R-La., said he understands why Senate Republicans want to preserve the filibuster.“It’s not my call. I don’t have a say in this. It’s a Senate chamber issue. We don’t have that in the House, as you know,” he told reporters on Friday. “But the filibuster has traditionally been viewed as a very important safeguard. If the shoe was on the other foot, I don’t think our team would like it.”Sen. John Fetterman, D-Pa., one of many Democrats who ran in 2024 on nixing the filibuster, said Republicans should go ahead and “carve it out” for government funding bills.”We ran on killing the filibuster, and now we love it,” he said. “I support it because it makes it more difficult to shut the government down in the future, and that’s where it’s entirely appropriate. And I don’t want to hear any Democrat clutching their pearls about the filibuster. We all ran on it.”Democrats have all but dared Republicans to kill the filibuster and fund the government on their own if they don’t want to negotiate to secure bipartisan support. On NBC’s Meet The Press NOW, Rep. Chris DeLuzio, D-Pa., said Republicans “should have” nuked the filibuster if they didn’t want to deal with Democrats on a bill.Republicans ‘should’ eliminate filibuster or work with Democrats on shutdown, House Democrat says08:33In his Thursday posts, Trump noted that Democrats tried in 2022 to smash the 60-vote threshold, in an attempt to pass a sweeping voting rights law. But they failed to secure the majority vote needed to change the rules in the Senate, and the effort fizzled.“If the Democrats ever came back into power, which would be made easier for them if the Republicans are not using the Great Strength and Policies made available to us by ending the Filibuster, the Democrats will exercise their rights, and it will be done in the first day they take office, regardless of whether or not we do it,” the president added.Two weeks after his proposal, NBC News asked Moreno if he had made progress convincing his GOP colleagues to nix the filibuster.“Not yet,” Moreno replied.Sahil KapurSahil Kapur is a senior national political reporter for NBC News.Ryan NoblesRyan Nobles is chief Capitol Hill correspondent for NBC News.Brennan LeachBrennan Leach is an associate producer for NBC News covering the Senate.
November 9, 2025
Alleged street racer charged after fatal car crash
November 4, 2025
Former Vice President Dick Cheney dies at 84
Comments are closed.
Scroll To Top
  • Home
  • Travel
  • Culture
  • Lifestyle
  • Sport
  • Contact Us
  • Politics
© Copyright 2025 - Be That ! . All Rights Reserved