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By Berkeley Lovelace Jr., Aria Bendix and Erika EdwardsPresident Donald Trump said Monday the Food and Drug Administration approved a chemotherapy drug called leucovorin as a treatment to alleviate symptoms of autism, despite little evidence that the medication works.Trump also said the administration is issuing a warning to doctors not to recommend acetaminophen — the active ingredient in Tylenol and other widely used medications — for pregnant women, claiming it may be linked to autism in children. Trump had been teasing the announcement for days, as Health Secretary Robert F. Kennedy Jr. and other health officials have pledged to determine the cause of the developmental disorder by September.The administration had planned to release its long-awaited report on causes of autism around Sept. 29 or Sept. 30, a person familiar with the matter told NBC News. But Trump pre-empted the rollout over the weekend, and details soon appeared in The Washington Post.“We understood a lot more than a lot of people who studied it,” Trump said from the White House, referring to autism. He spoke alongside Kennedy, Food and Drug Administration Commissioner Marty Makary, National Institutes of Health Director Jay Bhattacharya and Mehmet Oz, administrator of the Centers for Medicare and Medicaid Services. ”Taking Tylenol is not good,” Trump said. “I’ll say it. It’s not good.”Leucovorin is a drug approved by the FDA to counteract the side effects of certain chemotherapy drugs and sometimes used off-label to treat vitamin B9 deficiency. Leucovorin is a form of folinic acid, a B vitamin. It has shown promise in clinical trials with helping some children with autism improve their speech. But the Autism Science Foundation, which funds evidence-based autism research, does not recommend it as a treatment yet and says more studies are needed.Trump said the FDA updated the drug’s label Monday for the treatment of autism symptoms. Oz said Medicaid — in partnership with states — will cover it with a prescription.“We believe insurance companies will rapidly follow our lead,” he said.Kennedy also said the FDA will issue a letter advising health care providers that the over-the-counter medication should be used during pregnancy only in cases of high fever, when the fever itself may pose a health risk to the fetus. The FDA’s notice, sometimes called a “Dear Doctor” letter, is meant to alert physicians and other prescribers about urgent or clinically significant safety issues it has identified with a drug. Kennedy also said the FDA will begin the process to initiate a safety label change for the drug.Bhattacharya said at Monday’s briefing that the NIH will dedicate $50 million to 13 research projects focused on identifying root causes and treatments for autism, an effort known as the “autism data science initiative.” The research will focus on environmental and medical factors, nutrition, events during pregnancy, biology and genetics, he said.“Given this wide range of symptoms across the spectrum, it seems certain that there will be a wide range of biological contributors to explaining the cause,” he said.Researchers who’ve spent decades researching potential causes of autism say the administration hasn’t uncovered any new evidence — and the existing data still doesn’t support its claims.“This is not new,” Dr. Allison Bryant, a high-risk obstetrician at Massachusetts General Hospital in Boston, said in an earlier interview. “It has bubbled up every now and again with studies that show maybe some kind of association but not clearly showing any cause and effect.”Experts say autism spectrum disorder, which is characterized by challenges with social and speech skills and by repetitive behaviors, most likely stems from multiple factors rather than a single cause. It affects 1 in 31 children in the United States, according to the Centers for Disease Control and Prevention.The bulk of scientific research hasn’t identified a link between acetaminophen and autism.“The science hasn’t changed regardless of what comes out from the report,” said Brian K. Lee, a professor of epidemiology at Drexel University in Philadelphia, referring to the Trump administration’s finding. “I’m not sure what the administration is doing, but it looks like they’re just going back and reviewing the evidence and they’re coming to a different conclusion than many scientists would.”Acetaminophen was introduced in the United States in the 1950s as a prescription alternative to aspirin. By the 1970s, it had been made available over the counter and became one of the most commonly used pain and fever medications in the country. The American College of Obstetricians and Gynecologists and other major medical groups say acetaminophen is one of the only safe pain relievers for women during pregnancy, and studies have shown no clear evidence that use during pregnancy leads to developmental issues in kids. The drug is also found in name brands like Theraflu and Excedrin.Forty percent to 65% of women use acetaminophen at some point during pregnancy, according to a 2014 study published in the American Family Physician.Earlier Monday, White House press secretary Karoline Leavitt touted a “major announcement” from Trump, telling reporters at a briefing to go into the autism announcement with “some critical thinking skills and with some open ears.”“They are paying attention to studies, and the gold standard of science and research, that many in this city for far too long have turned a blind eye to,” she said.Trump administration officials are citing previous research, including a literature review Mount Sinai and Harvard researchers published last month in the journal BMC Environmental Health. The review concluded there was most likely an association between autism and acetaminophen exposure during pregnancy. Outside autism researchers, however, said that the review wasn’t rigorously conducted and that it cherry-picked studies that supported its conclusion. The review’s senior author, Andrea Baccarelli, served in 2023 as a paid expert in a class action lawsuit against acetaminophen manufacturers, in which he testified that there was a link between the medication and autism. A judge ultimately excluded his testimony for being scientifically unsound and last year dismissed the case, which is being appealed.Baccarelli said in a statement that he and his colleagues conducted a rigorous review and that the association with neurodevelopmental disorders was strongest when acetaminophen was taken for four weeks or longer. He said he discussed his findings with Kennedy and Bhattacharya in recent weeks.“Further research is needed to confirm the association and determine causality, but based on existing evidence, I believe that caution about acetaminophen use during pregnancy — especially heavy or prolonged use — is warranted,” Baccarelli said.However, other autism researchers have pointed to a large study last year published in the Journal of the American Medical Association, which found no link between acetaminophen use in pregnancy and autism, ADHD or intellectual disability. The study, from Lee and his colleagues in Sweden, analyzed data from more than 2.4 million children. When the researchers looked solely at children with autism, there was a small increased risk possibly associated with acetaminophen. But when the researchers compared siblings within the same families — one exposed during pregnancy, the other not — the link disappeared. The comparison allowed them to control for variables that past studies couldn’t. Siblings share a large part of their genetic background and often have similar environmental exposures in utero and at home.“The biggest elephant in the room here is genetics,” Lee said. “We know that autism, ADHD and other neurodevelopmental disorders are highly heritable.”In an emailed statement, a spokesperson for Kenvue, the maker of Tylenol, said the drug is the safest pain reliever option for pregnant women.“Without it, women face dangerous choices: suffer through conditions like fever that are potentially harmful to both mom and baby or use riskier alternatives,” the spokesperson said. “We believe independent, sound science clearly shows that taking acetaminophen does not cause autism.”Bryant, of Massachusetts General Hospital, said, “The best science that we have available would still suggest that acetaminophen is a safe pain reliever and fever reducer in pregnancy.”Berkeley Lovelace Jr.Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.Aria BendixAria Bendix is the breaking health reporter for NBC News Digital.Erika EdwardsErika Edwards is a health and medical news writer and reporter for NBC News and “TODAY.”

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Oct. 28, 2025, 7:07 PM EDTBy Abigail Williams, Courtney Kube, Carol E. Lee and Katherine DoyleWASHINGTON — Some of President Donald Trump’s aides have advised him against shifting the U.S. position on independence for Taiwan to favor China, according to four people with knowledge of the discussions, ahead of his meeting with Chinese President Xi Jinping this week.The aides have privately expressed concern that Trump, who is pushing to reach a sweeping trade deal with China, may choose to ignore their advice, the people with knowledge of the discussions said. They said they worry that Trump could walk away from long-standing U.S. policy on Taiwan or more subtly shift the U.S. position by framing it with new language.“Everyone is holding their breath,” one of the people with knowledge of the discussions said.Stocks hit record highs over hopes of China trade deal00:47Administration officials have told Trump to expect Xi to seek a public declaration from him that the United States “opposes” Taiwan’s independence, the people with knowledge of the discussions said. Xi has for months pushed for a shift in the U.S. position on Taiwan from the current one, which is that the United States does “not support” its independence, to saying the United States “opposes” it.While many Americans might see that as a different way of saying the same thing, were Trump to say the United States opposes Taiwan’s independence or even that independence is not a good idea at this time, it would send shock waves across Asia and be seen as a huge gift to Xi.Openly expressing opposition to Taiwan’s independence would be seen as moving the United States from a neutral position on the issue to clearly standing on the side of China. For decades, U.S. administrations have adopted a policy of strategic ambiguity toward Taiwan, known as the “One China” policy, and presidents have taken the public position of not supporting its independence.A White House official told NBC News: “President Trump has repeatedly affirmed that his Taiwan policy has not changed. President Trump leads on all foreign policy — he always puts forward deals that put the American people first.”Asked what the Trump administration’s policy on Taiwan’s independence was, a senior State Department official said, “The policy on Taiwan hasn’t changed one bit.”“It’s as consistent as it’s been for decades,” the official said Monday.China sees democratic and self-ruled Taiwan as a breakaway province that must be reunited with the mainland by military force if necessary. Taipei rejects Beijing’s claims of sovereignty and seeks to maintain its de facto independence even if it is not formally recognized by most countries.“The Taiwan question is at the core of China’s core interests, and the first red line that cannot be crossed in China-US relations,” Chinese Embassy spokesperson Liu Pengyu said by email when he was asked for comment.“There is but one China in the world, Taiwan is an inalienable part of China’s territory. This is a consensus of the international community and a political commitment made by the U.S. to China,” Liu said.Taiwanese officials are also uneasy about the upcoming Trump-Xi meeting and have expressed their own concerns to State Department officials that Trump could abandon Taiwan to secure a win from the meeting, one of the people familiar with the discussions said.Asked by reporters about Taiwan’s apprehension, Secretary of State Marco Rubio brushed the concerns aside.“What people are worried about is we’re going to get some trade deal where we’re going to get favorable treatment on trade in exchange for walking away from Taiwan,” Rubio said Saturday en route to Asia for this week’s meetings. “No one is contemplating that.”Taiwan’s Foreign Affairs Ministry took to social media soon after, expressing its appreciation to Rubio for “reaffirming no one is contemplating walking away from Taiwan.”Abigail Williams, Courtney Kube, Carol E. Lee and Monica Alba reported from Washington and Katherine Doyle from Tokyo.Abigail WilliamsAbigail Williams is a producer and reporter for NBC News covering the State Department.Courtney KubeCourtney Kube is a correspondent covering national security and the military for the NBC News Investigative Unit.Carol E. LeeCarol E. Lee is the Washington managing editor.Katherine DoyleKatherine Doyle is a White House reporter for NBC News. Monica Alba contributed.

October 28, 2025

By Megan Lebowitz, Ryan Nobles and Kelly O’DonnellWASHINGTON — The Republican-led House Oversight Committee asserted in a report Tuesday that some executive actions former President Joe Biden signed by autopen, including his pardons, were “illegitimate” because he suffered from mental decline while in office and could have been unaware of their contents.The committee’s Republicans said in the report that they deemed as “void all executive actions signed by the autopen without proper, corresponding, contemporaneous, written approval traceable to the president’s own consent.” In a letter accompanying the report, Committee Chair James Comer, R-Ky., urged Attorney General Pam Bondi to investigate Biden’s executive actions “to ascertain whether they were duly authorized by the President of the United States.” Before he left office, Biden issued several pardons for members of his family and key associates whom he said could be targets of political retribution by the Trump administration. Those included preemptive pardons for his two brothers and sister; Dr. Anthony Fauci; former Joint Chiefs of Staff Chairman Mark Milley; members of Congress involved in the Jan. 6 investigation and their staff, including now Sen. Adam Schiff, D-Calif.; and Washington police officers who testified before that panel. He had previously pardoned his son, Hunter Biden, of federal gun and tax charges after saying he would not do so.The report comes as the Justice Department investigates several of President Donald Trump’s opponents, sparking outrage from critics who argue that the prosecutions mark blatant retaliation against people whom the president dislikes. Trump has also asked Bondi to look into Biden’s cognitive fitness while in office and autopen use.Trump and other Republicans have long tried to cast doubts on the legitimacy of Biden’s use of the autopen, claiming he did not understand what he was authorizing — an allegation that has been routinely disputed by Democrats and the former president’s allies. Trump, too, has used an autopen, as have other presidents, and Comer has used a digital signature for letters and subpoenas in the investigation into Biden’s use of the autopen. A congressional committee does not have the constitutional authority to declare a presidential action null or void, but the findings could be used by the Department of Justice for an investigation or potentially as part of a legal challenge to certain executive decisions made by Biden, including pardons that he issued.The 100-page document also accuses the Biden administration and the former president’s allies of shielding his alleged cognitive decline from the American public. Comer asked Bondi to investigate actions from certain Biden aides, including former White House physician Dr. Kevin O’Connor, who invoked their Fifth Amendment right during their testimony. An attorney for O’Connor said during his deposition to the committee that “revealing confidential patient information would violate the most fundamental ethical duty of any physician.” The White House did not immediately respond to NBC News’ request for comment on the report, and a Justice Department spokesperson declined to comment.A spokesperson for Biden said in a statement that the House Oversight Committee’s “investigation into baseless claims has confirmed what has been clear from the start: President Biden made the decisions of his presidency.””There was no conspiracy, no cover-up, and no wrongdoing,” the spokesperson continued. “Congressional Republicans should stop focusing on political retribution and instead work to end the government shutdown.”The former president himself has rejected the committee’s claims, saying in a June statement, “Let me be clear: I made the decisions during my presidency.””I made the decisions about the pardons, executive orders, legislation, and proclamations,” he said at the time. “Any suggestion that I didn’t is ridiculous and false.”The former president also told The New York Times in July that he orally granted the pardons before they were signed with the autopen because of the large number of clemencies involved.Democrats on the House Oversight Committee remained highly skeptical of the Republicans’ report, arguing that it was a waste of the committee’s resources.The top Democrat on the committee, Rep. Robert Garcia of California, referred to the report as a “sham investigation” and argued that people who testified before the committee said “Biden fully executed his duties as President of the United States,” including the authorization of “every executive order, pardon, and use of the autopen.””While House Republicans obsess about President Biden’s health, they are ripping away healthcare from 17 million Americans and spiking premiums,” he said in the statement. “It’s clear the only person’s health that Republicans care about is Joe Biden’s.”Democrats have also questioned Trump’s health amid the release of vague summaries of his medical evaluations. Biden’s age and mental acuity, however, became a major concern within the Democratic Party after his disastrous debate performance against Trump last year ultimately led him op drop out of the 2024 race. Biden was diagnosed with an aggressive form of prostate cancer just months after leaving the White House.The House Oversight Committee report comes after the Justice Department has brought cases against several prominent Trump critics, including former FBI Director James Comey, New York Attorney General Letitia James, and former Trump national security adviser John Bolton, who have all pleaded not guilty to various charges against them. Those indictments were announced in the days and weeks after Trump pressured Bondi in a Truth Social post, claiming that several of his political foes were “guilty as hell” and saying “we can’t delay any longer, it’s killing our reputation and credibility.”In the post, Trump called for action to be taken against Comey and Schiff, and the Justice Department has launched a probe into the senator over allegations of mortgage fraud — which James is also facing in the case against her. Like James, Schiff has denied any wrongdoing.NBC News and other news outlets later reported that the Truth Social post was intended to be a direct message to Bondi rather than a public post. In a speech in Boston on Sunday, Biden argued the country is in one of “the worst of moments,” an apparent reference to the Trump administration’s policies and the level of political violence that has gripped the nation.”Over 50 years of elected public life, this is the worst I’ve seen it,” Biden said. He argued that “our very democracy is at stake” and urged Americans to “get re-engaged” and “fight like hell.”Megan LebowitzMegan Lebowitz is a politics reporter for NBC News.Ryan NoblesRyan Nobles is chief Capitol Hill correspondent for NBC News.Kelly O’DonnellChief Justice and National Affairs CorrespondentTara Prindiville contributed.

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