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Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleOct. 9, 2025, 3:53 PM EDTBy Kate Reilly and Saba HamedyJimmy Kimmel pressed comedian Aziz Ansari this week about his decision to perform at Saudi Arabia’s Riyadh Comedy Festival, with Kimmel calling the Saudi government a “pretty brutal regime” and questioning why Ansari would “take their money.”Held in Saudi Arabia’s capital city, the Riyadh Comedy Festival began on Sept. 26 and ends Thursday. The event has hosted over 50 stand-up comedians from around the world, including big names such as Ansari, Kevin Hart, Pete Davidson and Dave Chappelle. Those comedians have been facing backlash since accepting seemingly lucrative deals to perform in a country that has been criticized for its human rights violations.In an interview on “Jimmy Kimmel Live!” on Tuesday night, Kimmel pressed Ansari about his decision to take the stage in Riyadh. “People, a lot of comedians especially, are very upset, because the people who paid the comedians to come to this are not good people,” Kimmel said. “It’s a pretty brutal regime. They’ve done a lot of horrible, horrible things.” The talk show host then asked Ansari why he chose to appear at the event, stating that “people are questioning why you would go over there and take their money to perform in front of these people.”Ansari said he put a lot of thought into the decision, explaining that he consulted his aunt, who used to live in Saudi Arabia.”There’s people over there that don’t agree with the stuff that the government’s doing, and to ascribe like the worst behavior of the government onto those people, that’s not fair,” Ansari said his aunt pointed out. “Just like there’s people in America that don’t agree with the things the government is doing.”Kimmel agreed that “we’re doing horrible things over here,” but pushed back on Ansari’s comparison between the U.S. and Saudi Arabia. “They murdered a journalist,” Kimmel said, referring to Washington Post columnist Jamal Khashoggi, who was killed at the Saudi Consulate in Istanbul in 2018. Kimmel then asked Ansari if he had dealt “with those people specifically.”Ansari replied, “No, I was just there to do a show for the people.” The comedian further explained his thought process, saying his wife told him that “whenever there’s repressive societies like this, they try to keep things out — whether it’s rock ‘n’ roll music or blue jeans — because it makes people curious about outside ideas, outside values.”Ansari, who is Indian American, went on to add that “to me, a comedy festival felt like something that’s pushing things to be more open and to push a dialogue.” He then discussed how his own background compelled him to do the performance.”For me, especially being me and looking the way I do and being from a Muslim background, it felt like something I should be a part of. And I hope it pushes things in a positive direction.”Ansari did not immediately respond to an NBC News request for comment. When speaking to Bloomberg’s Lucas Shaw at the publication’s Screentime event on Wednesday, Kimmel — whose show recently returned to the air after it was briefly suspended by ABC and Disney over the host’s remarks about Charlie Kirk’s assassination — addressed why he pressed Ansari on the matter.“I wouldn’t have gone (to Riyadh), but I wanted to hear his reasons,” said Kimmel, who also noted that Ansari was aware he would ask him about the festival.“Nothing’s black and white,” Kimmel added. “It’s not something I would do, but I do understand the idea that if we close ourselves off to the world … maybe that’s not good. I don’t know that my reasoning is correct reasoning.”He drew a parallel to current U.S. politics. “We see it happening in this country, too,” he said. “We travel abroad, many of us don’t want to be held accountable for what our president does and says.” Kimmel’s skepticism about the Riyadh Comedy Festival comes after many comedians have publicly criticized the event.”WFT” podcast host Marc Maron ripped into the festival in a stand-up clip posted to Instagram on Sept. 23. “I mean, how do you even promote that?” Maron said. “Like, ‘From the folks that brought you 9/11, two weeks of laughter in the desert. Don’t miss it.’”Shane Gillis also condemned the event on his podcast, and said that the festival organizers “doubled the bag” after he declined to perform. Human Rights Watch wrote in a press release published on Sept. 23 that the Saudi government is using the comedy festival “to deflect attention from its brutal repression of free speech and other pervasive human rights violations.”The Saudi Embassy in Washington, D.C., and Saudi Arabia’s General Entertainment Authority, which announced the festival in July, did not immediately respond to requests for comment.Kate ReillyKate Reilly is a news associate with NBC News.Saba HamedySaba Hamedy is the trends and culture editor for NBC News.

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Jimmy Kimmel pressed comedian Aziz Ansari this week about his decision to perform at Saudi Arabia’s Riyadh Comedy Festival, with Kimmel calling the Saudi government a “pretty brutal regime” and questioning why Ansari would “take their money.”Held in Saudi Arabia’s capital city, the Riyadh Comedy Festival began on Sept. 26 and ends Thursday.



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Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleOct. 15, 2025, 5:08 PM EDTBy Kaitlin SullivanTwo months after she was born, Eliana Nachem got a cough that wouldn’t go away. Three weeks later, she also started having runny stool, prompting a visit to her pediatrician. Eliana didn’t have allergies or a gastrointestinal condition; instead, tests pointed to a problem with her immune system. At 4 months old, Eliana received her diagnosis: severe combined immunodeficiency, or SCID. Babies born with the extremely rare disease do not develop the cells required for a functioning immune system. Every germ becomes a potentially fatal threat and to stay healthy, children with the condition must live in a completely sterile environment. Without treatment, kids usually do not live past their second birthday.“I expected the worst, then I immediately went into research mode,” Eliana’s father, Jeff Nachem, said. The Nachems also got to work turning their home into a germ-free fortress, rehoming their pets, never opening the windows and opening the doors to outside as sparingly as possible. Eliana was kept inside, and on the rare instance when visitors came by, the family had disposable gowns, gloves and masks for them to wear. (SCID is sometimes referred to as “bubble boy disease.”) Eliana also started on a temporary therapy that replaced a missing enzyme in her body, called adenosine deaminase (ADA).In the midst of the strict protocol, they learned about a clinical trial in Los Angeles — 2,600 miles from their home in Fredericksburg, Virginia — that could help their daughter live a normal life.Jeff, Caroline and Eliana Nachem with Dr. Donald Kohn before Eliana’s gene therapy for ADA-SCID.Courtesy Caroline NachemScientists have identified about 20 gene variants that cause SCID. Eliana’s form of the disease, ADA-SCID, is diagnosed in fewer than 10 children born in the U.S. each year. (Under 100 babies are diagnosed with any form of SCID in a given year.)In 2014, when she was just 10 months old, Eliana was one of 62 children enrolled in a clinical trial for a gene therapy for ADA-SCID. In a study published Wednesday in the New England Journal of Medicine, researchers followed up on the results of that Phase 2 clinical trial. The update reported that all 62 kids, who received the treatment from 2012 to 2019, are alive today. In 59 of them, including Eliana, the gene therapy completely restored immune function, without requiring any additional treatment — a success rate of 95%.“This is one of the most successful gene therapy trials for an ultra-rare genetic disease that we have,” said Dr. Talal Mousallem, an associate professor of pediatrics at the Duke University School of Medicine. He was not involved with the trial. Correcting stem cellsThe treatment begins with doctors harvesting stem cells from the patient’s own bone marrow. These stem cells are purified in a lab, and then modified using an inactivated form of the virus that causes HIV. Instead of carrying the human immunodeficiency virus, this version carries the ADA gene that people with ADA-SCID are missing, reinserting the gene into the stem cell DNA. Before the customized treatment is reinfused back into the patient, they must undergo chemotherapy to get rid of the body’s existing stem cells and make room for the new ones. Once back in the body, the cells — which no longer carry the virus, just the gene it left behind — get to work building an immune system over the next year.“It’s a one-time delivery vehicle that takes the gene into the DNA of the stem cell, so every time it divides to make other cells, those cells carry that ADA gene,” said Dr. Donald Kohn, a pediatric bone marrow transplant physician at UCLA’s Broad Stem Cell Research Center, who led the trial. A less risky optionGene therapy clinical trials are underway for four subtypes of SCID, but the standard of care is still a bone marrow transplant, which builds an immune system using stem cells from a donor. The treatment can be risky and side effects further down the line.It’s ideal for bone marrow transplants to occur between siblings — who share about half of the same DNA — but two siblings only have about a 25% chance of being a match. In most cases, the donor is not a sibling, which introduces the risk that the donor’s immune cells will attack the recipient’s body, a phenomenon called graft-versus-host disease.The risk of graft-versus-host means kids who receive functioning stem cells from another person have to be on immunosuppressant drugs following the transplant, which keep the foreign cells from attacking their immune system.“Which slows down the progress, because you are suppressing the immune system while also trying to build an immune system,” Kohn said. People also have to undergo much higher doses of chemotherapy before receiving a donor bone marrow transplant than they do before undergoing gene therapy. “There can be effects [later in life] from being treated with chemotherapy, including growth, endocrine or fertility effects,” said Dr. Whitney Reid, an attending physician in the division of allergy and immunology at Children’s Hospital of Philadelphia, who was not involved in the trial. With gene therapy, “you can give those patients much lower doses of chemotherapy and there is a much lower chance of rejection,” she said. Eliana “was able to go from living in isolation to being able to go to preschool and go swimming in a public pool and play on a playground, and do all the things that every other kid gets to do,” her father said. Courtesy Caroline Nachem Having another therapy for ADA-SCID is particularly important, Reid added. Changes in the ADA gene cause toxins to build up in clumps of white blood cells called lymphocytes. This can cause hearing loss and learning difficulties as kids get older. Unlike other types of SCID, “it doesn’t only affect the immune system,” Reid said. Mousallem, of Duke University, said he hopes the success of this trial will open the door to gene therapies for other rare diseases that often go untreated, as well as SCID caused by other gene variants. “The data is great for ADA-SCID, and it is our hope that one day this becomes the standard of care,” he said. Eliana turns 12 years old next week and loves going to dance classes.“It’s amazing that she was able to go from living in isolation to being able to go to preschool and go swimming in a public pool and play on a playground, and do all the things that every other kid gets to do,” her father said. Eliana still undergoes testing twice a year to make sure her immune system hasn’t weakened. So far, so good.“We think it’s a lifelong therapy,” Kohn said. “Some of these kids are now 15 years old and are living normal lives. We treated them when they were little babies and now they’re going to prom.”Kaitlin SullivanKaitlin Sullivan is a contributor for NBCNews.com who has worked with NBC News Investigations. She reports on health, science and the environment and is a graduate of the Craig Newmark Graduate School of Journalism at City University of New York.
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