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Carolinas declare states of emergency, brace for storm threat

admin - Latest News - September 28, 2025
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North Carolina and South Carolina declared states of emergency over the weekend as a developing storm system churns in the tropics. That system could impact the Carolinas, Georgia and Florida as soon as next week, as a major hurricane already spins in the Atlantic. NBC News’ Jesse Kirsch reports from Charleston, South Carolina.



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By Dennis Romero and Bella LoBueThree people were killed and eight others were injured when someone on a boat opened fire on patrons of a waterfront eatery at a North Carolina marina on Saturday night, a city official said.The boat paused in front of American Fish Company at Southport Yacht Basin and a gunman opened fire, said ChyAnn Ketchum, spokesperson for the city of Southport.Details on the conditions of the injured were unavailable.The shooter fled toward the adjacent Intracoastal Waterway, Ketchum said. A person of interest was being questioned late Saturday, the spokesperson said.The earlier report of an active shooter at the marina prompted a law enforcement response. The city of Southport in a statement had urged people in the area to “remain in your homes” and report anyone suspicious to authorities via 911.The Brunswick County Sheriff’s Office said that it is one of multiple law enforcement agencies in the region that responded to the incident.”Please keep all those affected, as well as our first responders, in your thoughts and prayers,” the sheriff’s office said.The yacht basin exists in the southeastern corner of the state “where the Intracoastal Waterway, Cape Fear River and Atlantic Ocean converge,” according to state tourism organization Visit North Carolina.The basin is lined with restaurants, it says.This is a developing story. Please check back for updates.Dennis RomeroDennis Romero is a breaking news reporter for NBC News Digital.Bella LoBueBella LoBue is a Assignment Editor at NBC News Digital. Insiya Gandhi contributed.
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Sept. 28, 2025, 5:00 AM EDTBy Berkeley Lovelace Jr.Last winter, Brian Noonan read online that some doctors were prescribing an obscure drug, typically given to cancer patients, for autism. Curious, he looked into it for his son Benjamin, who had just been diagnosed with autism in October.“We jumped on it,” Noonan said. “It felt right and it made sense.”The medication was leucovorin, also called folinic acid. It’s a synthetic form of vitamin B9 or folate, which the body needs to make healthy blood cells. During pregnancy, folate is important to reduce the risk of birth defects.Last Monday, the drug was thrust into the national spotlight by President Donald Trump in a rambling press conference about autism that mainly focused on the president and Health Secretary Robert F. Kennedy’s claim that taking acetaminophen during pregnancy could cause autism. Trump briefly mentioned that an “existing drug” — referring to leucovorin — may help with certain symptoms of autism. For those in the autism community, leucovorin is not new. Dr. Richard Frye, a behavioral child neurologist in Phoenix has studied leucovorin and autism for two decades. He made clear that it is not a cure for autism and that more research is needed. He does, however, prescribe it to some people with autism.Noonan’s son Benjamin, who is 4 years old, is one of Frye’s patients. “He’s higher functioning,” Noonan said. “He’s verbal, but he really struggled to put together sentences.” Since starting on the medicine, the family believes Benjamin’s speech has improved, though he still has difficulties with hyperactivity and impulsiveness.Still, Noonan added, he’s under no impression that the drug is a miracle pill. Benjamin also attends a behavioral program preparing him for kindergarten, Noonan said, and he plans to enroll him in speech and occupational therapy. “We very, very much understand we’re still taking an experimental medication,” he said. The Noonan family. Benjamin, 4, who has autism, has used leucovorin.Courtesy of Brian NoonanOther families say the drug conferred larger benefits.Ben Blomgren, of Minneapolis, said his 11-year-old son, Josh, had been prescribed leucovorin off-label in February after he was at risk of being kicked out of school, even as they tried behavioral modification methods.“He’s pretty severe,” Blomgren said. “He didn’t have any language skills. He was not toilet trained.” After starting the medication, Blomgren said Josh’s sleep improved, he’s fully toilet trained and he’s stopped running away from them. “It wasn’t overnight, but we saw major improvement,” he said. Yomarie Miranda, of Florida, said she saw improvements in her 7-year-old son Ethan after he started the medication, including following instructions in class.Ethan was prescribed the medication off label earlier this month, she said.“He’s now looking at me when I speak with him. He’s talking more than before with complete sentences,” she said.A highly unusual moveThe Food and Drug Administration first approved leucovorin in the 1980s to help reduce the toxic side effects of certain chemotherapy drugs.In the decades since, researchers have also studied whether it might treat cerebral folate deficiency (CFD), a neurological condition that makes it harder for folate to reach the brain. Some children with autism also have cerebral folate deficiency, which neurologists say can affect speech, mood and behavior. Last Monday, the FDA said it planned to update the drug’s label to include that use.But the agency’s decision, experts say, rests on just a handful of small studies. And despite Trump’s endorsement, the maker of the brand-name version, GSK, has yet to submit an application to the agency to change the label. In a statement, GSK said it will be submitting the request to expand the approval to include cerebral folate deficiency, though the statement does not mention autism. (Because leucovorin is already an FDA-approved drug, doctors have been able to prescribe it “off label” for other uses, though insurance may not cover it.) It’s a highly unusual move for the FDA: pushing a drug for chemotherapy side effects as a therapy for autism without a formal submission and limited evidence.“It’s incredibly irresponsible,” said Dr. Aaron Kesselheim, a professor of medicine at Harvard Medical School. “For 60-plus years, we’ve counted on the FDA to help patients distinguish between products that work and products that don’t work. And here we saw the FDA making an announcement relying on a summary of unclear data and announcing that they had already decided to approve it.”Alycia Halladay, chief science officer at the nonprofit Autism Science Foundation, was frustrated by the implication that this is a breakthrough in autism research.“It’s not like scientists have just been staring at their belly buttons for 20 years, not looking at autism treatments,” Halladay said in an interview earlier this week. “They have, but the standards have been very high to get [treatments] approved.”Andrew Nixon, a spokesperson for the Department of Health and Human Services, which oversees the FDA, said in a statement: “Analysis across 23 publications from 2009-2024 demonstrated the effectiveness for CFD. Overall, 85% of patients experienced some type of clinical benefit including improved speech/communication capabilities.” Nixon’s statement did not mention autism, and he did not respond to follow-up questions.David Mandell, a psychiatry professor at the University of Pennsylvania, said HHS’ claim that 85% of patients experienced a benefit is a “quite a conceptual leap” because it assumes people with cerebral folate deficiency also have autism.Cerebral folate deficiency “is an extremely rare event, and it is accompanied by symptoms of epilepsy, really severe neurodevelopmental problems and some of those symptoms can look like autism, but it’s not,” he said.“I could not think of a single FDA approval that has such weak evidence in the past 20 years,” Mandell added.Frye, the Phoenix neurologist, estimates up to three-quarters of autistic children have antibodies linked to cerebral folate deficiency, based on his research. Other estimates are much lower: Alycia Halladay, chief science officer at the nonprofit Autism Science Foundation, put the rates at roughly 10% to 30%.The studies on leucovorin are small but look interesting, said Dr. Scott Gottlieb, a former FDA commissioner.“It certainly merits follow up,” Gottlieb said.One of the studies was conducted by Frye: a placebo-controlled trial of more than 40 children with the antibodies, published in Molecular Psychiatry in 2018. It found around two-thirds of kids who got the drug saw improvements in verbal communication after 12 weeks. Others saw no changes. The children all had language impairments, as well as a common type of autism that’s not linked to other neurological diseases.Mandell, however, said the results shouldn’t be taken as evidence.“They claim that in certain subgroups of kids in their already small sample, they find these very large effects,” he said, adding that larger-scale trials that establish clear outcomes ahead of time are needed to verify the results. Kesselheim said it’s important for patients to have access to medications that could have a benefit, especially when there is an unmet medical need. But, he said, there are still a number of unanswered questions.“There is no accurate testing for this,” he said. “What are low folate levels? What are normal folate levels? All of that stuff should be worked out.”Frye said he currently uses two methods to assess whether a child has a folate deficiency: a spinal tap — also known as a lumbar puncture — which involves inserting a needle into the lower back to collect fluid from the spinal cord, and a folate receptor antibody test originally developed for pregnant women that isn’t approved by the FDA for diagnosing folate deficiency in children. Edward Quadros, a research professor at SUNY Downstate Health Sciences University who has worked with Frye studying leucovorin for autism, said parents are already trying the drug, including supplement versions, which aren’t regulated and can be dangerous.“By making the FDA approve it, and reputable pharmaceutical companies manufacturing it and selling it, at least it gives you quality dosing,” Quadros said.Berkeley Lovelace Jr.Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.Aria Bendix contributed.
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Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleOct. 6, 2025, 10:27 AM EDT / Updated Oct. 6, 2025, 3:11 PM EDTBy Gary Grumbach and Dareh GregorianIllinois filed a lawsuit Monday in an attempt to block the Trump administration from deploying federalized National Guard troops on the streets of Chicago. “The American people, regardless of where they reside, should not live under the threat of occupation by the United States military, particularly not simply because their city or state leadership has fallen out of a president’s favor,” the Illinois attorney general’s office wrote in the filing, which names President Donald Trump, Homeland Security Secretary Kristi Noem, Defense Secretary Pete Hegseth and Army Secretary Daniel Driscoll as defendants.“The Trump administration’s illegal actions already have subjected and are subjecting Illinois to serious and irreparable harm,” the suit says.The White House maintained Trump’s actions are lawful.“Amidst ongoing violent riots and lawlessness, that local leaders like [Illinois Gov. JB] Pritzker have refused to step in to quell, President Trump has exercised his lawful authority to protect federal officers and assets. President Trump will not turn a blind eye to the lawlessness plaguing American cities,” said White House spokeswoman Abigail Jackson.Representatives for the Justice Department, U.S. Army and Department of Homeland Security did not immediately respond to request for comment. The Pentagon declined to comment.The legal action comes after a federal judge in Oregon issued two separate orders over the weekend temporarily blocking the Trump administration from sending federalized National Guard members from California — or any other state — to Portland, Oregon. Portland and Chicago are part of a wave of Democrat-run cities and states that Trump has targeted with federal troops.“This country has a longstanding and foundational tradition of resistance to government overreach, especially in the form of military intrusion into civil affairs,” U.S. District Judge Karin Immergut, a Trump appointee, wrote in one of her rulings.The suit brought on behalf of Illinois and the city of Chicago makes similar arguments about federal overreach.“The Federalization Order’s deployment of federalized military forces to protect federal personal and property from ‘violent demonstrations’ that ‘are occurring or are likely to occur’ represents the exact type of intrusion on State power that is at the heart of the Tenth Amendment,” the suit says.“The deployment of federalized National Guard, including from another state, infringes on Illinois’s sovereignty and right to self-governance. It will cause only more unrest, including harming social fabric and community relations and increasing the mistrust of police. It also creates economic harm, depressing business activities and tourism that not only hurt Illinoisians but also hurt Illinois’s tax revenue,” the suit says.The city and the state want a judge to declare the administration’s federalization and deployment of the National Guard of the United States, any state National Guard, or deployment of the U.S. military in Illinois as “unconstitutional and/or unlawful.” Trump had been threatening to send the National Guard into Chicago for months, and gave the green light to do so over the weekend. “Amidst ongoing violent riots and lawlessness, that local leaders like [Illinois Gov. JB] Pritzker have refused to step in to quell, President Trump has authorized 300 national guardsmen to protect federal officers and assets,” White House spokeswoman Abigail Jackson said in a statement.The suit denies there’s any emergency in the city or that there’s a need for federal troops. “The supposed current emergency is belied by the fact that Trump’s Chicago troop deployment threats began more than ten years ago,” the suit says, pointing to a 2013 Trump tweet where he wrote, “we need our troops on the streets of Chicago, not in Syria.” He’s since worked to “demonize cities where Democrats had been elected as leaders,” and provoked unrest in the state by surging federal law enforcement to target undocumented immigrants and protesters outside of an immigration detention facility in the suburb of Broadview, the suit says.”Among other things, Trump and Noem have sent a surge of SWAT-tactic trained federal agents to Illinois to use unprecedented, brute force tactics for civil immigration enforcement; federal agents have repeatedly shot chemical munitions at groups that included media and legal observers outside the Broadview facility; and dozens of masked, armed federal agents have paraded through downtown Chicago in a show of force and control,” the suit says. “The community’s horror at these tactics and their significant consequences have resulted in entirely foreseeable protests,” it added.Pritzker, in an interview Sunday on CNN’s “State of the Union,” said federal authorities “are the ones that are making it a war zone” in Chicago. Trump has threatened to send the National Guard into other prominent Democratic-run cities against their wishes as well, including New York, Baltimore and New Orleans. The warning comes as the rate of serious crimes has dropped dramatically in those cities and in Chicago in recent years. Statistics from the Chicago Police Department show the murder rate through the end of September is down 29% compared to the same time period last year. Overall crime is down 13%, according to CPD. Trump previously deployed National Guard troops to Los Angeles and Washington, D.C. In early September, a federal judge in California ruled that Trump’s deployment of Marines and National Guard members there was illegal. D.C.’s Democratic attorney general has also sued to challenge the deployment of troops in the capital.
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