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Dec. 7, 2025, 4:56 PM ESTBy Andrew GreifAfter being snubbed by the College Football Playoff, Notre Dame has pulled itself out of the postseason entirely.Hours after being left out of the 12-team playoff, the Fighting Irish announced that “as a team, we’ve decided to withdraw our name from consideration for a bowl game following the 2025 season,” the university’s football team posted on X.“We appreciate all the support from our families and fans, and we’re hoping to bring the 12th national title to South Bend in 2026.”The Fighting Irish played in last season’s national championship game but were on the playoff bubble this fall after a 10-2 record, including an opening-week loss at Miami. Notre Dame was ranked in the top 10 of every ranking by the playoff selection committee until Sunday’s final rankings, when it fell to 11th and was the first team left out. Meanwhile Miami (10-2) earned the final at-large berth.The Fighting Irish had won 10 consecutive games and were idle Saturday, but fell anyway. Athletic director Pete Bevacqua called the previous rankings a “farce and total waste of time” to ESPN.How a committee would view Miami and Notre Dame had been a subplot all season. The committee’s chairman, Hunter Yurachek, had said that Miami’s head-to-head win wasn’t a significant factor — until Sunday, when BYU’s drop in the rankings after its loss in the Big 12 championship moved Miami up, creating a head-to-head comparison between the schools.Notre Dame joined Iowa State and Kansas State in declining a bowl bid despite being eligible, although the circumstances were far different; the Cyclones and Wildcats are each going through coaching transitions. The Big 12 Conference fined both schools $500,000 for saying no to the postseason.Andrew GreifAndrew Greif is a sports reporter for NBC News Digital. 

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After being snubbed by the College Football Playoff, Notre Dame has pulled itself out of the postseason entirely.



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November 13, 2025
Nov. 13, 2025, 11:00 AM ESTBy Kaitlin SullivanEating more ultra-processed foods is tied to an increased risk of precancerous colorectal growths in women under 50, according to a study published Thursday in JAMA Oncology.These growths, called adenomas or polyps, can later turn into cancer and are a good indicator of a person’s cancer risk, experts say.Rates of colorectal cancer in people under 50 have risen sharply in recent decades. The findings could offer new insights into what’s driving this increase.“One approach we’ve been taking is trying to understand what has changed in our environment that could be driving this. What are some trends that mirror this acceleration in cancer rates?” said study leader Dr. Andrew Chan, a gastroenterologist and the chief of the clinical and translational epidemiology unit at Massachusetts General Brigham in Boston.Ultra-processed foods now make up the bulk of the average American’s diet, especially among kids. The foods, which tend to be high in calories, have been linked to depression, Type 2 diabetes and early death. Some experts have also suspected eating these foods could be driving the increase in colorectal cancer rates among young people.To test this hypothesis, Chan and his team used data from more than 29,000 women who participated in the Nurses’ Health Study II, an ongoing study of female registered nurses established in 1989. The women, who were between 24 and 42 when they enrolled in the study, were followed for 24 years, from 1991 through 2015. Every four years, everyone filled out a questionnaire about their diets, and everyone had at least one colonoscopy before 50.The researchers looked at whether the women were diagnosed with precancerous polyps: either adenomas, which are more likely to turn into cancer, or serrated lesions. While only about 5% of adenomas are cancerous, about 75% of colorectal cancers start as adenomas, according to the Cleveland Clinic. Serrated lesions are still considered precancerous but are linked to fewer cases of colorectal cancer, Chan said.The study found a connection between eating more ultra-processed foods and developing an adenoma before 50. It didn’t see any links between the foods and serrated lesions.Because the majority of colon cancers arise from adenomas, the study showing a link between eating more ultra-processed foods and an increased risk of developing adenomas specifically gave Chan and his team more confidence that these foods could increase colorectal cancer risk, he said.“The strength was that we looked at two major types of polyps — it’s the adenoma type that seems to underlie cancer, and we saw the link between that,” he said. “About 1,200 women in the study developed adenomas. Compared to those who ate the fewest ultra-processed foods, those who ate the most — accounting for one-third of their daily calories — were about 1.5 times more likely to develop adenomas. Specific foods also appeared to increase risk. Diets higher in sugar and artificial sweeteners were most linked to higher rates of adenomas, followed by diets high in sauces, spreads and condiments.Although the study included only women, the majority of whom were white, other studies have also found a link between men eating more ultra-processed foods and developing cancer.“We don’t have any reason to believe there would be a difference in men compared to women,” Chan said, adding that additional research should include men to be sure.Most colorectal polyps do not turn into cancer, but nearly all colorectal cancer does start as a polyp, said Dr. Folasade May, a gastroenterologist and an associate professor of medicine at the David Geffen School of Medicine at UCLA, who wasn’t involved with the research.This is why doctors remove any polyps they find during a colonoscopy, and why people who have polyps are considered to be at higher risk for developing colorectal cancer. “They are looking at the first step, who is more likely to get these polyps that can turn into cancer,” May said of the study.The problem is that routine screening for colorectal cancer does not happen until age 45, said Dr. Christopher Lieu, the co-director of gastrointestinal medical oncology at the University of Colorado Anschutz School of Medicine in Aurora.“The concern is that whenever you have a polyp in a young person, that polyp is allowed to grow unnoticed, and because you are not screening those young patients,” Lieu said. This makes it even more important to identify the modifiable lifestyle factors that are driving increased rates of colorectal cancer in young people, added Lieu, who wasn’t involved with the new research.Although scientists have yet to determine a clear cause, the rise in rates is unlikely to be driven by genetics, May said.“This has happened very fast, so it is likely unfortunately something we have done to ourselves as humans, in the way we live our lives,” she said. “It’s jarring, hearing stories every week about people in their 20s, 30s, 40s getting cancers that, when I was in medical school, we were taught happen in people in their 80s.”Ultra-processed foods cause inflammation in the gut — which includes the colon — that impairs the gut’s ability to repair itself when damaged and keep tumors at bay. High levels of inflammation are also linked to cancer in general, May said. Another hypothesis is that people who eat more ultra-processed foods are more likely to have obesity and Type 2 diabetes, both which are linked to a higher risk for colorectal cancer.“More likely, it’s the direct toxic effects of these ultra-processed foods,” May said.Chan, the study author, said ultra-processed foods are known to alter the gut microbiome, which, in theory, could make cells in the gut more likely to turn cancerous.The next step in the research is determining whether any of these hypotheses appear to have a causal effect on who develops colorectal cancer at a young age. It’s likely part of the puzzle, Chan said.“One thing that has been clear is that the U.S. intake of ultra-processed food has really risen in the past few decades in a way that mirrors the staggering increase in colorectal cancer cases,” he said.Kaitlin SullivanKaitlin Sullivan is a contributor for NBCNews.com who has worked with NBC News Investigations. She reports on health, science and the environment and is a graduate of the Craig Newmark Graduate School of Journalism at City University of New York.
October 23, 2025
Oct. 22, 2025, 2:08 PM EDTBy Elizabeth CohenWhen a radiologist reviewed Deirdre Hall’s mammogram images last summer, everything seemed fine. There were no shadows or lumps or irregular patches that could signal cancer.The doctor gave it a second look for one reason: artificial intelligence software had drawn a circle around an area in the upper part of her left breast that it found suspicious.Because the AI software had put up that red flag, Hall, 55, got an order for an ultrasound that led to a biopsy. There were four cancerous tumors in the spot AI had identified.“This would have been completely missed without the AI,” said Dr. Sean Raj, chief medical officer and chief innovation officer at SimonMed Imaging in Tempe, Arizona, where Hall had her mammogram.Not only was Hall’s breast tissue dense, but the layers of tissue crisscrossed over each other in a particularly complicated pattern.“It camouflaged the cancer,” said Raj, a breast imaging specialist. “Even I could have missed it.”They caught her cancer at Stage 1, said Hall, who’s a respiratory therapist at a local hospital.“They didn’t find anything in the lymph nodes, which they were grateful for,” she said. “I’m so glad they caught it early.” “I’m glad it was found,” Deirdre Hall said about the software program that detected suspicious images on her mammogram.Courtesy Deirdre HallWhen reading women’s routine mammograms, radiologists are increasingly augmenting their eyes with artificial intelligence. While many major medical centers have adopted the technology enthusiastically, some experts point to concerns, including a lack of studies in the U.S. showing that AI actually saves lives and does not needlessly raise concerns about benign growths. Experts train AI software by feeding it hundreds of thousands, or sometimes millions of mammogram images. Some of the images contain cancerous tumors, and, over time, the AI learns to distinguish the often subtle differences between malignant and benign tissue. Some AI programs, like the one used on Hall, identify a suspicious area. Others predict the chance that a woman will develop breast cancer. At the University of California, San Francisco, researchers are using AI to try to speed up the time from a mammogram to cancer diagnosis. In a study released this week, the radiologists used the technology to flag suspicious-looking mammograms so those patients could be seen more quickly. For patients with breast cancer, that AI triage cut the average time from mammogram to biopsy by 87%, from 73 days to nine days. The study was posted Tuesday to the preprint server MedRxiv. (Studies posted to preprint servers have not been peer-reviewed.) AI software used by SimonMed Imaging, where Hall had her mammogram, marked an area suspicious for cancer.Courtesy Deirdre HallHowever, Dr. Sonja Hughes, vice president of community health at Susan G. Komen, a breast cancer organization, said more research is needed before AI is used as the standard of care. “We’re not there yet,” she said. “We don’t have enough research or enough data.”Dense breasts: Finding a snowball in a blizzardMammograms have saved countless lives, but they’re imperfect. Dense breast tissue, which is a risk factor for developing cancer, makes mammograms harder to interpret. About 40% of U.S. women have dense breasts, according to the American Cancer Society. “It’s like trying to find a snowball in a blizzard,” said Dr. Otis Brawley, a professor of oncology and epidemiology at Johns Hopkins University.The Food and Drug Administration has authorized many AI programs for mammograms, with varying rates of accuracy. The AI software used on Hall’s mammogram, called Lunit, accurately identified cancers 88.6% of the time, according to a 2024 JAMA Oncology study of more than 8,800 women in Sweden who got mammograms. Another study published in Radiology noted that AI software caught cancers that were missed by two radiologists. However, in the Sweden study, AI gave a false positive 7% of the time, saying there might be a tumor when there wasn’t one. A false positive can trigger more testing and anxiety while waiting for results. With any mammogram, the chance of having a false positive result is about 10%, according to research.A doctor interprets the screening’s resultsMajor academic medical centers using AI in their imaging centers include the MD Anderson Cancer Center, the Mount Sinai Hospital in New York City, the Perelman Center for Advanced Medicine at the University of Pennsylvania, the Siteman Cancer Center at Barnes-Jewish Hospital, and MedStar Health.In all centers, the software is used along with, not instead of, a radiologist’s eyes, as FDA regulations require a doctor to interpret mammograms. Some breast imaging experts see advantages to this human-machine combination.“The nice thing about AI is that it doesn’t get tired,” said Dr. Lisa Abramson, associate professor of radiology at Mount Sinai. “It’s not going to replace the job or the expertise of radiologists, but I think it’s only going to enhance our ability to detect more and more breast cancers.”Brawley, the Johns Hopkins professor, said AI could help women who don’t have access to radiologists who specialize in breast imaging, and instead have their mammograms read by general radiologists.A study using RadNet’s software found that without AI, specialists correctly identified breast cancers 89% of the time, compared with 84% for generalists. With AI, the accuracy for both groups rose to about 93%.“It’s incredibly subjective when a human reads a mammogram,” Brawley said. “Maybe it’s going to reduce the disparities in how these things are read.”Does AI cost more? Typically, academic medical centers don’t charge patients extra for the use of AI software, and they can’t charge insurance companies for it, since there’s no billing code specifically for the AI, according to Susan G. Komen, a nonprofit breast cancer organization. SimonMed, which has centers in 11 states, and RadNet, which has centers in eight states, don’t charge for an initial layer of AI on mammograms, although patients are charged $40 and $50 respectively if they opt to have their images run through a second set of the technology.Drawbacks of AIBrawley worries that AI might be too good at its job.According to the American Cancer Society, it’s possible that mammograms flag some tumors that are technically cancerous, but not life-threatening. The patient then undergoes the physical, emotional, and financial toll of treating a tumor that was never going to hurt her.“It’scancer, but it’s not genetically programmed to grow, spread, or kill,” Brawley said. “I am worried that AI may help us find even more of these tumors that don’t need to be found.”Brawley pointed to the lack of data in the U.S. that shows AI actually saves women’s lives.Last month, researchers at the University of California, Los Angeles and University of California, Davis, announced a $16 million, two-year study at seven medical centers to take a deeper look at the technology.There are several other concerns about using AI in mammography. The technology isn’t perfect, and some worry that doctors could make mistakes if they become too dependent on it, according to an article last year in RadioGraphics. That’s why radiologists emphasize that AI is a tool, not a solution in itself. “It’s not going to replace the job or the expertise of radiologists,” said Abramson, the breast radiologist at Mount Sinai. “I think it’s only going to enhance our ability to detect more and more breast cancer.” Another concern is that if AI is trained mainly on breast images of white women, it could be less accurate for women of color, since genetic differences can make tumors look different.Hall, the Arizona patient, said she’s not necessarily a fan of AI in general — she says she finds the technology “creepy” — but she’s glad she paid $50 for the extra AI on her mammogram. “I don’t love all this AI stuff, but I definitely love this for me or anyone else in my position,” she said. “No matter how it was found, I’m glad it was found.” Guidance for mammogramsGuidance from the United Services Preventive Services Task Force recommends women to get a mammogram every other year starting at age 40. According to American Cancer Society guidelines:Women 45 to 54 should get mammograms every year.Women 55 and older can switch to a mammogram every other year, or they can choose to continue yearly mammograms.Dr. Shanthi Sivendran, senior vice president at the American Cancer Society, offers guidance for more accurate breast cancer screening. Try to go to the same place every year so radiologists can compare your images over time.Ask if a center uses radiologists who’ve completed a fellowship in breast imaging. In some rural or underserved areas, it may be harder to find these specialists, and so women should seek out radiologists who primarily read breast images. Try to find a center that can either provide or direct you to follow-up care, such as additional imaging, in case your mammogram finds something suspicious. According to FDA regulations, your mammogram report should state if you have dense breasts. If you do, ask your doctor about whether you might need additional imaging tests. Elizabeth CohenElizabeth Cohen is a Peabody Award-winning journalist and a health contributor to NBC News. She is the author of the book “The Empowered Patient.” 
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Oct. 22, 2025, 5:24 AM EDT / Updated Oct. 22, 2025, 5:35 AM EDTBy Alexander Smith and Daryna MayerJust hours after President Donald Trump said peace talks with Russia’s Vladimir Putin were on hold to avoid wasting his time, the Kremlin launched intense overnight strikes that killed at least six people in Ukraine.Ukrainian officials said the Russian attacks on Kyiv and other cities were the latest proof that Putin was not ready for peace and merely wanted to use negotiations to drag out the war.Asked about Trump’s remarks, the Kremlin said Wednesday that neither president wanted to waste time — and cautioned that any meeting would require further “preparation.”Two children were among those killed in the overnight strikes on the Ukrainian capital and other cities, President Volodymyr Zelenskyy said in a post. In total over the past 24 hours, at least 13 people were killed and dozens others injured in Russian attacks across Ukraine, according to local officials.An apartment building damaged by a drone strike in Zaporizhzhia, southern Ukraine, on Wednesday.Stringer / ReutersAs in previous years, when the frigid months are about to bite, Russia has targeted energy facilities in an attempt to put Ukrainians in the cold and dark.“Another night proving that Russia does not feel enough pressure for dragging out the war,” Zelenskyy said. He called on Western allies to supply Ukraine with long-range missiles capable of striking deeper into Russia, saying that Moscow had been emboldened to up its attacks by Kyiv’s current lack of such capabilities.“Russia continues to do everything to weasel out of diplomacy,” he said in his nightly address. “The greater Ukraine’s long-range reach, the greater Russia’s willingness to end the war.”A firefighter works at the site of a Russian strike in Zaporizhzhia.State Emergency Service Of Ukraine In Zaporizhzhia Region / via ReutersThe attacks came after Trump confirmed his much anticipated meeting with Putin in Hungary had been shelved.“I don’t want to have a wasted meeting; I don’t want to have a waste of time,” Trump said, adding that he would “see what happens” as events played out.Asked about Trump’s comments Wednesday, Putin spokesman Dmitry Peskov told reporters that neither Trump nor Putin “wants to waste time.” He called them “two presidents who are accustomed to working effectively and efficiently, but effectiveness always requires preparation.”The American president’s remarks came after Russian Foreign Minister Sergey Lavrov reasserted Tuesday that Russia opposed an immediate ceasefire before talks begin.”This is the basic difference which is existing now between Russia and the United States,” Andrei Fedorov, former deputy foreign minister of Russia, told NBC News in an interview in Moscow on Wednesday.Putin and his team have not shifted publicly during these talks about talks, insisting on hardline demands and balking at the insistence from Kyiv and its European allies to halt fighting along current lines before conducting deeper negotiations.Trump this week echoed that European position.Though Trump has claimed victories in helping calm other global conflicts, Ukraine — a war he once said he could solve in 24 hours — has so far proved more difficult. He has variously sought to strongarm Zelenskyy and Putin with few tangible results.Trump essentially pressed pause on his latest effort, believing both sides in the conflict were not ready to seriously talk peace, after he was briefed on a “productive” call between Lavrov and Secretary of State Marco Rubio, a senior White House official told NBC News. The Kremlin insisted it wanted to adhere to what it said was agreed in Alaska between Trump and Putin.Jae C. Hong / APDespite this, the would-be host of the Trump-Putin summit said it could still happen.Viktor Orban, Hungary’s Prime Minister who is a long-time ally of Trump’s and has warm relations with Putin, said that his ambassador in Washington was still working on the meeting.”Preparations for the peace summit continue,” Orban wrote on Facebook. “The date is still uncertain. When the time comes, we will organize it.”Alexander SmithAlexander Smith is a senior reporter for NBC News Digital based in London.Daryna MayerDaryna Mayer is an NBC News producer and reporter based in Kyiv, Ukraine.Keir Simmons and Natasha Lebedeva contributed.
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