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Israel Accuses Hamas of Violating Ceasefire, Strikes Gaza

admin - Latest News - October 19, 2025
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The ceasefire between Israel and Hamas appears to be showing cracks with reports that fighting has resumed. NBC’s Richard Engel reports for Sunday TODAY.



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Oct. 19, 2025, 8:45 AM EDTBy Kaitlin SullivanCovid vaccines may come with a tantalizing benefit that has nothing to do with the virus they’re designed to protect against: boosting the immune system to better fight tumors during cancer treatment.That’s according to new results presented Sunday in Berlin at the European Society for Medical Oncology conference. The research is still in the earlier stages — it has yet to be tested in a Phase 3 clinical trial — but experts say it shows promise.“I am cautiously optimistic,” said Stephanie Dougan, an associate professor of cancer immunology and virology at the Dana-Farber Cancer Institute, who was not involved with the work. “There is a scientific logic to why this could work.”Researchers found that among cancer patients getting immunotherapy, those who got an mRNA Covid vaccine within 100 days before starting their treatment lived longer.Only about 20% of cancer patients who get immunotherapy — which harnesses a person’s immune system to fight cancer cells — respond to the treatment. Finding a way to boost the effectiveness of immunotherapy drugs has been a feat researchers have been exploring for years, with little success.Typically, the immune-stimulating tactics employed in the past have either done too little to activate the immune system or done too much, triggering an overactive response that can damage the body. There’s a chance that mRNA Covid vaccines could exist in a Goldilocks zone.“Maybe we just needed something that was medium-strong, and this could potentially be it,” said Dougan, who emphasized the need for more research.That research will soon be underway: Dr. Adam Grippin, a senior resident in radiation oncology at the University of Texas MD Anderson Cancer Center who co-led the study, said his team is launching a Phase 3 clinical trial to confirm the initial results.In the research presented Sunday, Grippin and his co-authors looked back at survival rates among more than 1,000 people who had advanced non-small cell lung cancer and got immunotherapy as part of their treatment from 2019 through 2023. Of those, 180 people received an mRNA Covid vaccine within 100 days of starting treatment.The median survival for the group — when exactly half of those who underwent treatment are still alive — was nearly twice as long for those who were vaccinated compared to those who were not: about three years compared to just over 1.5 years.The researchers also compared the survival rates in a smaller group of patients getting immunotherapy for metastatic melanoma. Forty-three got an mRNA Covid vaccine; 167 did not. For those who didn’t get vaccinated, median survival was just over two years. Those who were vaccinated prior to treatment hadn’t yet reached their median survival point more than three years into follow-up.In further experiments in mice, the researchers got an answer they believe matches the way the vaccines work in humans.“It superdrives the immune system against tumors,” Grippin said.Creating a beaconVaccines that use mRNA are already a promising area of cancer research. Scientists have developed personalized mRNA cancer vaccines that are tailored to fight a person’s unique tumor, as well as ones that target genes that are commonly found in certain types of cancer, including pancreatic. (These developments come as the Trump administration has canceled half a billion dollars in funding for mRNA vaccine research for infectious diseases.)If Grippin’s later trial confirms the results of the early research, it could represent the next frontier for research on mRNA vaccines and cancer.Immunotherapy drugs work by boosting the immune system’s ability to fight cancer, often by enhancing the power of immune cells called T cells that attack invaders, or by making tumors easier for T cells to find.The mouse portion of the new research found that Covid mRNA vaccination appeared to make the immune system more attuned to recognizing tumors as a threat by stimulating dendritic cells, a type of white blood cell. When dendritic cells detect a threat, they turn on a sort of beacon that leads T cells to the perceived invader so they can attack. However, not everyone naturally has T cells that are capable of fighting tumors, which is why scientists believe immunotherapies only work in some of the cancer patients who take them. In these people, the immune system recognizes cancer cells as a threat, but their specific T cells are unable to stop the tumors from growing.“It’s just random chance whether you have those cells or you don’t,” said Jeff Coller, a professor of RNA biology and therapeutics at Johns Hopkins Medicine, who was not involved with the research.Getting an mRNA Covid vaccine doesn’t change whether a person has the specific T cells needed to fight their tumors, but it does appear to make it more likely that dendritic cells will detect a tumor as a problem and direct the T cells a person does have to the tumor. If those cells happen to be programmed to be able to kill tumor cells, having an mRNA vaccine that lights up the target before a person starts an immunotherapy can give their immune system a boost that helps the cancer therapy work better.Coller said one reason mRNA technology may be the best tool to elicit this response is because every cell in the body already contains mRNA.“We are really tapping into that natural process that your body already knows how to respond to,” he said. “You are using your body’s natural system to fight tumors.”Dougan said it’s possible that other factors could have accounted for better survival among people who were vaccinated prior to immunotherapy treatment. For example, a Covid infection may have weakened an unvaccinated person’s body and hindered their ability to fight off cancer cells. In the past, early studies like this one have shown promising results that didn’t pan out in later trials. “We have been misled by retrospective studies before,” she said.Grippin agreed the findings warrant a closer look. “This data is exciting, but all of these findings need to be validated in Phase 3 clinical trials to determine whether these vaccines should be used in our patients,” he said.Kaitlin SullivanKaitlin Sullivan is a contributor for NBCNews.com who has worked with NBC News Investigations. She reports on health, science and the environment and is a graduate of the Craig Newmark Graduate School of Journalism at City University of New York.
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Nov. 25, 2025, 11:10 PM ESTBy Gary Grumbach and Raquel Coronell UribeThe Justice Department said Tuesday that Homeland Security Secretary Kristi Noem was the Trump administration official behind the decision not to comply with a federal judge’s order to halt the deportation of alleged Venezuelan gang members to El Salvador under the Alien Enemies Act.In a court filing, the Justice Department said administration officials conveyed U.S. District Judge James Boasberg’s March 15 oral order to return alleged Venezuelan members of the Tren de Aragua gang to the United States, as well as the subsequent written order the same day that blocked the federal government from removing members subject to the Alien Enemies Act under President Donald Trump’s invocation of the 18th century law.The filing said Justice Department officials relayed the order and provided legal advice to the acting general counsel for the Department of Homeland Security, who conveyed that advice, as well as his own, to Noem. Noem then decided that detainees under the Alien Enemies Act who were removed from the United States before the court’s order could be transferred to El Salvador.A DHS spokesperson did not immediately respond to a request for comment on the Justice Department filing Tuesday night.Judge finds probable cause to hold Trump administration in contempt over deportation flights03:29The filing, which came 255 days after 261 people were loaded onto three planes in the United States bound for El Salvador, reveals for the first time who in the Trump administration was responsible for making the final decision. It comes as Boasberg said he wanted to revive criminal contempt proceedings against administration officials who authorized the deportation flights.The Justice Department’s disclosure is an attempt to provide Boasberg with information he has requested for months in an effort to avoid high-ranking officials’ being ordered to publicly testify about their actions that day.Chief U.S. District Judge James Boasberg in Washington, D.C., on Nov. 3.Saul Loeb / AFP – Getty Images fileBoasberg barred the administration from deporting alleged Tren de Aragua members using the wartime Alien Enemies Act in March, saying the deportees most likely did not receive due process. The administration executed flights carrying deportees under the act anyway.The Justice Department has argued that Boasberg’s written injunction halting the deportations had no bearing on those already removed from the country. In the filing Tuesday, the administration maintained that its decision was “lawful” and “consistent with a reasonable interpretation of the court’s order.”The decision to authorize the flights came amid the administration’s early showdown with judges who ruled against some of Trump’s policies and tactics.In April, the Supreme Court threw out Boasberg’s decision while still saying detainees must receive due process. That approach to due process has continued in other courts.A whistleblower alleged in June that former Principal Deputy Attorney General Emil Bove — who the court said Tuesday was one of the Justice Department officials who provided DHS with legal advice — had told subordinates they would need to consider ignoring court orders. Bove denied the accusations during Senate confirmation hearings for his nomination to the 3rd U.S. Circuit Court of Appeals. “I have never advised a Department of Justice attorney to violate a court order,” he said.The whistleblower is one of the people Boasberg indicated he intends to hear testimony from in any contempt proceedings.The Trump administration is seeking a final ruling from Boasberg on the issue, and it could appeal after that. But Boasberg is pushing to get to the bottom of what happened on March 15 and why his orders weren’t followed. An appeals court allowed him to continue with contempt proceedings this month.Plaintiffs want to put at least nine past or present Trump administration officials on the witness stand for a contempt hearing.The list of potential witnesses includes Bove, a 3rd Circuit appeals judge; whistleblower Erez Reuveni, formerly acting deputy director of the Justice Department’s Office of Immigration Litigation; and Deputy Assistant Attorney General Drew Ensign, whom the Justice Department filing pointed to Tuesday as having conveyed Boasberg’s oral and written orders to DHS.Gary GrumbachGary Grumbach is an NBC News legal affairs reporter, based in Washington, D.C.Raquel Coronell UribeRaquel Coronell Uribe is a breaking news reporter. 
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