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Oct. 20, 2025, 12:33 PM EDTBy Rebecca CohenThe news is out and the internet is thrilled: Colman Domingo will voice the Cowardly Lion in “Wicked: For Good.” “Wicked” director Jon M. Chu teased the news in a Thursday interview with Deadline, saying that it will be “wild” when the actor who is voicing the part — a major Hollywood star, per Chu — steps on the red carpet. But the news was instead revealed Monday, when the “Wicked” movie Instagram account posted a video of Domingo playing with and surrounded by a number of stuffed toy lions. “See you in Oz,” Domingo says in the video with a wink. Users on social media spent the weekend speculating who might be playing the part, with rumors centering on former late-night host and musical theater actor James Corden. When the news was announced Monday, those same users celebrated the casting — and the fact that the role didn’t go to Corden. “James Corden isn’t the lion in wicked! We won,” one X user posted. In order to book Domingo in the part originally made famous by Bert Lahr in the 1939 film adaptation of “The Wizard of Oz,” Chu told Deadline he sent the “Sing Sing” actor a direct message on Instagram. “I was like, ‘It’s not a ton of lines, but maybe you have a little time. I know you’re busy. I’ll come to you,'” Chu recalled saying in the message, according to Deadline. Chu said Domingo responded “‘Why the f— not, let’s go!’ And then we went ahead and recorded the lines.”Domingo joins an already star-studded cast, including Ariana Grande as Glinda, Cynthia Erivo as Elphaba and Jonathan Bailey as Fiyero. “Wicked: For Good,” the second in a two-part series, releases in theaters on Nov. 21. It will continue the story told in last year’s “Wicked.” The film is produced and will be distributed by Universal Pictures, which is owned by NBCUniversal, the parent company of NBC News.Rebecca CohenRebecca Cohen is a breaking news reporter for NBC News Digital.

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The news is out and the internet is thrilled: Colman Domingo will voice the Cowardly Lion in “Wicked: For Good.”



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Oct. 20, 2025, 1:45 PM EDTBy David CoxPeople with a leading cause of blindness were able to read again thanks to a tiny wireless chip implanted in the back of the eye and specialized augmented glasses, according to study results published Monday in the New England Journal of Medicine. The trial involved 38 European patients, all of whom had an advanced stage of dry age-related macular degeneration (AMD) known as geographic atrophy. There is no cure for AMD, which is driven by changes in a part of the retina called the macula and caused by inflammation and a build-up of waste. The photoreceptor cells in the macula are responsible for producing sharp, detailed and colored vision. When the disease has progressed to the geographic atrophy stage, these cells deteriorate and die, and people lose their central vision — meaning that an object straight ahead may appear blurry or covered up with a dark blotch. Roughly 22 million people in the U.S. have AMD, and about 1 million have geographic atrophy, according to the American Macular Degeneration Foundation.In the study, the participants, who had an average age of 79, were fitted with the “PRIMA device,” a system meant to replicate vision. Patients wear augmented reality glasses embedded with a camera that captures their visual field. What the camera “sees” is transmitted to the chip implanted in their eye in the form of infrared light. The chip converts the light into an electrical current, which stimulates the remaining healthy cells in the macula in a realistic way, enabling signals these cells send to be interpreted by the brain as vision. An image processor, which the user must carry, lets patients zoom in and magnify the images they see, which appear in black and white.The image on the right shows what the camera sends to the user’s implanted microchip.Science Corporation With the help of the PRIMA device, 80% of the 32 patients who returned for a reassessment one year after the chip implantation had achieved clinically meaningful visual improvements. Patients did experience side effects, predominantly related to the surgical procedure: The study reported that 26 serious adverse events occurred in 19 of the patients, ranging from elevated blood pressure in the eye to an accumulation of blood around the retina. The majority of the adverse events resolved within two months of the implantation. “It’s the first ever therapeutic approach that has led to an improvement in visual function in this group of patients,” said Dr. Frank Holz, the trial’s lead investigator and chair of the department of ophthalmology at the University Hospital of Bonn in Germany. “Late-stage age-related macular degeneration is a dismal disease. Patients are no longer capable of reading, driving a car, watching TV or even recognizing faces. So [these results] are a game-changer in my mind.”One patient, Sheila Irvine, 70, who was fitted with the PRIMA device at Moorfields Eye Hospital in London, said in a statement provided by the hospital that her life before receiving the implant was akin to “having two black discs in my eyes, with the outside distorted.” A self-described “avid bookworm” before losing her vision, Irvine said she was now able to do crosswords and read prescriptions.Dr. Sunir Garg, professor of ophthalmology at the retina service of Wills Eye Hospital in Philadelphia, who was not involved in the study, said the results represent a breakthrough for patients with geographic atrophy. All doctors have been able to offer, he said, are visual aids, like magnifiers, and emotional support.“Even with new medical therapies, the best that we can do is slow it down,” said Garg, who works with several drugmakers involved in treatments for AMD, including Apellis Pharmaceuticals, the maker of pegcetacoplan. That drug, which slows the progression of geographic atrophy, was recently approved in the U.S. and must be injected into the eye every 1 to 2 months. “We can’t stop it, and we can’t do anything to bring back lost vision.” An actor wearing the PRIMA system glasses.Science CorporationDr. Demetrios Vavvas, director of the retina service at Mass Eye and Ear in Boston, who was also not involved in the study, said that the PRIMA system is not without limitations. Vavvas noted that the surgery required to implant the chip in the eye requires a high level of surgical skill and is not without risk. “You have to lift the retina off its normal position to implant this device, which increases the atrophy,” said Vavvas, who is a consultant to Sumitomo Pharmaceuticals, a company working on stem cell therapies for patients with other forms of vision loss. Vavvas said it was important to note that the device isn’t restoring normal vision, as patients were only able to see in black and white rather than color, and the trial participants had to undergo a significant amount of training in order to learn how to see with the PRIMA device. He also said that it wasn’t clear whether the enhancements in visual ability had significantly improved the patients’ quality of life.But at the same time, Vavvas was also optimistic about its future potential, describing the current iteration of PRIMA as a key stepping stone in the field of vision restoration. “Think of this device as the pre-release iPhone,” he said. “The limitations are clear. We shouldn’t oversell that the quality of life really improved. But there were certain [visual] tasks at which the patients were clearly better. So it shows to us that there is potential in this approach. It is still in some ways, a prototype. They’re working on iterations of this device that will be better.”New upgrades to the PRIMA device could be coming in the next couple of years. The PRIMA system was invented by Stanford University ophthalmology professor Daniel Palanker and is being developed by the California-based neural engineering company Science Corporation.Palanker said technical improvements are being made to increase the number of pixels in the chip from 400 to 10,000. The new chips have already been tested in rats, and the upgraded chips are being manufactured for future human trials. With the aid of the camera’s zoom function, Palanker said that this could theoretically enable patients to achieve 20/20 visual resolution.The microchip shown next to a penny.Science Corporation“We are also working on next generation software that will allow patients to perceive not just black-and-white text, but also grey-scale natural images, such as faces,” Palanker said.Palanker suggested that the technology could be trialed in other retinal diseases that cause blindness, such as Stargardt disease, which has similar symptoms to age-related macular degeneration but is genetic and usually affects younger people. Garg and Vavvas are eager to see larger trials that provide more details about how the device improves patients’ ability to function on a day-to-day basis. Vavvas suggested that future trials should include a control arm to understand the extent to which the device yields real-world benefits, for example compared to existing electronic magnifiers. “Is it something that is good enough for patients to say, ‘Well, I’ve regained my independence because I can now do my credit card bills myself, stamp and address my envelopes myself, and look at grocery store labels?’” Garg said. “Those kinds of practical things I would like to know more about.”“This is a chronic disease that you will have for life, so we need more than one year of follow-up to see other risks, other problems,” Vavvas said. “Does that signal of efficacy that we see at 12 months, remain two years later?”While Vavvas said he would not call the device a complete panacea for blindness, the study showed that brain-computer interfaces can represent an important approach to tackling different kinds of severe visual impairment. “As the iterations of this device become better and better, it could become a real solution for a cohort of patients,” he said. David CoxDavid Cox is a freelance journalist focusing on all aspects of health, from fitness and nutrition to infectious diseases and future medicines. Prior to becoming a full-time journalist, he was a neuroscientist attempting to understand how and why the brain goes wrong.
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Oct. 23, 2025, 9:00 AM EDTBy Aria BendixResearchers have identified a surprising cause of some urinary tract infections: contaminated meat.A four-year study found that nearly 1 in 5 UTIs detected among a group of patients in Southern California were most likely caused by the consumption of chicken, turkey, pork or beef that carried E. coli bacteria.The common understanding is that most UTIs are caused by improper hygiene or sexual contact. Around 6 million to 8 million cases are recorded in the United States every year, and around 80% are caused by E. coli bacteria. But the strains responsible for the majority of UTIs are not the ones typically associated with foodborne illnesses, which cause diarrhea and vomiting.The new research, published Thursday in the journal mBio, hints at the prevalence of foodborne UTIs, which were largely unknown to scientists two decades ago.“This is the latest in a long series of studies that have shown that we’re getting some of our urinary tract infections from food,” said Dr. Martin Blaser, a microbiologist at Rutgers University, who was not involved in the research.“A study like this allows people to draw inferences, to understand what’s going on,” he added. “If somebody develops a urinary tract infection, they’re now wondering, ‘Well, was it the hamburger I ate three days ago or five days ago?’”When E. coli bacteria from food wind up causing a UTI, they first enter the gut after people touch contaminated meat in the cooking process or eat undercooked meat. From there, the bacteria can get into the urethra as a result of poor hygiene or improper wiping in the bathroom, then ascend into the urinary tract.One of the study’s authors, Lance Price, a professor of environmental and occupational health at George Washington University, said he was inspired to investigate the link between UTIs and contaminated meat about 15 years ago, when he noticed that most of the chicken and turkey he tested carried the bacterium. “For some reason, that was basically being ignored. If it didn’t cause diarrhea, it was being ignored. And so that started me on this path,” he said.Price’s previous research estimated, based on modeling, that foodborne E. coli could account for up to 640,000 UTIs in the United States every year — around 8% of the total. His new findings come from a collaboration with researchers at Kaiser Permanente, who collected more than 2,300 urine samples that were positive for E. coli in Southern California from 2017 to 2021. They also took more than 3,300 samples from meat sold in major grocery stores in the area over the same period.A lab at George Washington University then analyzed the genetic material to determine the origins of people’s infections.“Strains have different DNA signatures, and you can see whether the strains in the animals and the strains in the people match up or not. And they found a number of matches,” Blaser said.Among the meat sampled, contamination rates were highest in chicken and turkey products. The study also found that low-income neighborhoods in Southern California had a 60% higher risk of foodborne UTIs than wealthier neighborhoods. Price and his co-authors suggested that grocery stores in those areas might not have proper storage temperatures or that they may keep products out for too long. Price said he has seen poorly packaged meat sold in some stores in Washington, D.C.“I would buy these packages of chicken that were just bloated, just so full of saline that when I put it on the conveyor belt … it would just be wet,” he said. “And I know what’s in that liquid: It’s bacteria, and often drug-resistant bacteria, that’s spilling onto these conveyor belts.”Urinary tract infections can cause painful and frequent urination, and if they are left untreated, they can lead to serious or life-threatening complications, so people with suspected UTIs should seek treatment right away.“The bladder is a major gateway to the bloodstream for E. coli. And when you get these E. coli in your blood, they can kill you,” Price said.Doctors treat UTIs with the same antibiotics regardless of whether the E. coli originated from contaminated meat or another source. (Doctors and patients rarely know the source of an infection, Price said.)Although thoroughly cooking meat and poultry can kill bacteria, Price said, the transmission of foodborne E. coli is mostly due to cross-contamination in the kitchen, so it is important to keep raw meat separate from other items and wash your hands thoroughly after you prepare food.His study also recommends that meat producers and regulatory agencies consider stricter measures to limit E. coli contamination, such as making sure packages are sealed tightly and do not contain excess liquid. “Everybody should have leak-proof packaging in the United States,” he said.Aria BendixAria Bendix is the breaking health reporter for NBC News Digital.
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