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Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleNov. 16, 2025, 4:31 PM ESTBy Megan LebowitzWASHINGTON — The U.S. military carried out another strike on an alleged drug boat in the eastern Pacific on Saturday, killing three people, according to a Sunday post to X from the U.S. Southern Command.The latest strike is at least the 21st that the military has conducted on alleged drug boats during the second Trump administration, prompting concerns from some lawmakers.The U.S. Southern Command’s post said the strike was at the direction of Defense Secretary Pete Hegseth. The post alleged that the boat was “operated by a Designated Terrorist Organization” and was “trafficking narcotics in the Eastern Pacific,” adding that the strike took place in international waters.“Intelligence confirmed that the vessel was involved in illicit narcotics smuggling, transiting along a known narco-trafficking route, and carrying narcotics,” the post said.NBC News has not independently confirmed the military’s account of the strike. The administration has not provided evidence supporting its allegations about the vessel or the people on board.Video released by U.S. Southern Command appears to show the strike causing a large wave to spike up next to the boat, which is then engulfed in flames.The announcement came days after NBC News previously reported that the Trump administration carried out its 20th such attack, according to a Pentagon official. That strike took place in the Caribbean Sea. Previous attacks took place in both the Caribbean and the eastern Pacific, and they have killed more than 75 people, according to officials.Sunday’s announcement came the same day the USS Gerald R. Ford, a major aircraft carrier, arrived in the Caribbean.The strikes have generated controversy in Congress, as Democrats and some Republicans paint the administration’s moves as heavy-handed overreach that circumvents lawmakers.But in October, the Senate rejected a resolution requiring Trump to obtain congressional approval for military strikes in the Caribbean. Earlier this month, the Senate voted down a similar resolution that would require the president obtain congressional approval for any military action against Venezuela.Republican Sens. Lisa Murkowski of Alaska and Rand Paul of Kentucky sided with Democrats to push for a congressional authorization requirement.Paul previously said in an October interview on NBC News’ “Meet the Press” that the strikes “go against all of our tradition.” He raised concerns over people being killed without the administration providing evidence of a crime, noting the possibility that some of those killed could be innocent.Megan LebowitzMegan Lebowitz is a politics reporter for NBC News.Mosheh Gains, Courtney Kube and Frank Thorp V contributed.

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WASHINGTON — The U.S. military carried out another strike on an alleged drug boat in the eastern Pacific on Saturday, killing three people, according to a Sunday post to X from the U.S.



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Savewith a NBCUniversal ProfileCreate your free profile or log in to save this articleNov. 16, 2025, 7:56 AM ESTBy Lindsey LeakeDo you know what your hormone levels are? Should you?Your body is home to more than 50 hormones — chemical messengers that compose the endocrine system — and hormonal changes may reflect any number of medical conditions. For example, low levels of the pancreatic hormone insulin may indicate diabetes, while high levels of the stress hormone cortisol can play a role in obesity.But some hormones such as melatonin, which is important for sleep, naturally fluctuate throughout the day. Other hormonal changes are normal at different phases of life, such as a woman’s drop in the reproductive hormones estrogen and progesterone preceding menopause.Hormones are having a moment.The Food and Drug Administration announced Nov. 10 it was removing the black box warning on hormone replacement therapy for menopause. Agency leaders said the listed risks, including breast cancer, don’t outweigh the treatment’s long-term health benefits, such as reductions in bone fractures and cognitive decline.The news has sparked interest among women who may be candidates for the therapy. Dr. Mary Jane Minkin, a clinical professor of obstetrics, gynecology and reproductive sciences at the Yale School of Medicine, joked that her patients have since been “going wild.”In an age when over-the-counter hormone tests are a dime a dozen and supplements boast of alleviating hormonal imbalances, it can be tough to know whether you may need hormonal testing and treatment or are falling prey to marketing schemes.Dr. Jan Shifren, director of the Midlife Women’s Health Center at Massachusetts General Hospital, said women experiencing perimenopause, the years leading up to their final menstrual period, are a prime target for such “meno-profiteering” or “meno-washing,” the practice of selling pseudoscience for women during menopausal transition.“I actually never use the words ‘hormone imbalance’ with my patients,” Shifren said. “There are a lot of people out there marketing very expensive hormone testing — often not covered by insurance — these very large panels of multiple hormones that essentially tell us nothing.”The U.S. endocrine testing market, which encompasses hormone tests, has flourished since the pandemic, according to Grand View Research, an international consulting and market research firm. Its market size was about $4.1 billion in 2022 and is estimated to soar at a 7.7% compound annual growth rate from 2024 to 2030, mirroring global projections.While hospitals commanded the global endocrine testing market in 2023, commercial laboratories are expected to see the fastest annual growth through 2030, projections show.In the U.S., commercial labs such as Labcorp and Quest Diagnostics offer prescription-free options ranging from a single $49 test measuring the luteinizing hormone, which helps regulate the menstrual cycle, to an in-depth hormone panel exceeding $500.Numerous telehealth companies sell similar tests, which may involve blood, urine or saliva collection, with some approaching $1,000 per panel. HealthLabs.com, for example, offers a “comprehensive female hormone panel” that measures hormones including estrogens, thyroid hormones, testosterone and human growth hormone. The panel, which also includes tests for cholesterol, folic acid and vitamin B12, has a list price of $1,598 but was on sale for $799 as of Nov. 13.“I see women in my practice all the time who have spent $600 for an online consult, they’re spending $600 or $700 every few months for a very large panel of unnecessary hormone levels,” Shifren said. “Then when they come to see me, I don’t want to look at any of those levels. I want to talk to them about what’s bothering them, what their symptoms are.”Follow the symptoms, not hormone levelsPerimenopause typically begins between the ages of 45 and 55 and can last up to a decade. Menopause marks a single point in time, 12 months after a woman’s final period, followed by postmenopause for the rest of a woman’s life.More than 1 million women in the U.S. reach menopause each year, at age 52 on average, according to the National Institute on Aging.“Half of all people on this planet will go through menopause if they’re fortunate enough to live long enough,” Shifren said. “That’s an important time of life.”Tired of Feeling Tired? Why You May Need a Cortisol Reset04:28It can also be a time when quality of life diminishes for women experiencing symptoms, which may include hot flashes and night sweats, brain fog, mood swings, weight gain, painful sex, breast tenderness, incontinence, insomnia, vaginal dryness and irregular periods.When Minkin sees a patient in her 40s or 50s with such symptoms, treatment is the goal — no hormone testing needed.“In general, I try to discourage people [from testing] as much as possible,” Minkin said. “Particularly in the perimenopausal situation, hormones fluctuate all over the place.”Not to mention, Minkin said, even a premenopausal woman’s reproductive hormones vary widely throughout her cycle.Minkin also advises patients against purchasing hormone panels on their own.“My standard example is, if I have a patient who’s 53 years old … hasn’t had a period for three months and she’s up every night, sweating and not sleeping and not feeling good, and she wants her hormone levels tested,” Minkin said. “[I’d] say to her, ‘Please, go out and buy a dress with that money. I can tell you you’re perimenopausal.’”Similarly, older women don’t often benefit from sex hormone testing, Shifren said.“There’s absolutely no reason to check estradiol [a form of estrogen] or progesterone in a postmenopausal woman,” Shifren said. “We can tell them — before they spend any money — that those levels are low.”Who would benefit from hormone testing?When it comes to perimenopausal symptoms, age matters, said Dr. Shamita Misra, a clinical professor of family and community medicine at the University of Missouri School of Medicine.Menopause occurring between the ages of 40 and 45 is considered early, while reaching the milestone younger than 40 constitutes premature menopause. Roughly 5% of women hit early menopause naturally, as opposed to the condition being induced by surgical or other medical interventions, according to the federal Office on Women’s Health.Because early or premature menopause is associated with a higher risk of conditions including heart disease and osteoporosis, a patient under 40 reporting perimenopausal symptoms may benefit from hormone testing, Misra said.“Are we suspecting premature menopause, or is there any other endocrine problem?” Misra said. “We have to be open and not just focus on perimenopause. We have to also get [the patient’s] history.”On the other hand, if you’re of normal perimenopausal age and dealing with symptoms, don’t shy away from discussing any hormonal concerns you may have with your health care provider, Misra said. Shared, informed decision-making is your safest option.“Some women don’t talk candidly about their symptoms,” Misra said.If your doctor does recommend hormone testing, keep in mind that some medications, including birth control, may affect your levels.“You would have to be off birth control for 90 days — minimum three months — before your hormones get back to being at their baseline,” Misra said. “When a person is breastfeeding, for example, when a person is on oral contraception or some hormones already, it’s impossible to check for hormone levels accurately.”Risks from unnecessary hormone testingIt’s natural to be curious about hormone levels — reproductive or otherwise — whether you’re symptomatic or not, doctors say. Some of Dr. Debra Bell’s patients have told her they need data to feel comfortable about their health, even when she doesn’t need data to treat them.“My approach is, How will this test help us in our decision-making for your situation?” said Bell, director of education at the Osher Center for Integrative Health at the University of Washington School of Medicine. “It doesn’t always help.”But just because hormone testing isn’t typically beneficial for peri- and postmenopausal women doesn’t mean it’s harmless, Bell said. Cost is one such harm.“I know people who have maxed out their credit card for these kinds of things,” Bell said.Not all over-the-counter menopause diagnostics are pricey. For instance, pharmacy chains and big-box stores sell rapid menopause test sticks hovering around $30, sometimes less.The questions then become: How accurate are the results and who’s interpreting them?“If [a patient has] done the test, then I will interpret it for them,” Bell said. “A lot of times, what the test shows is what we might already presume based on the symptoms they’re having and what’s happening with their menstrual cycle.”Another danger in self-testing is self-treating one’s perceived hormone imbalance, Bell said. Unlike prescription medications, the FDA doesn’t approve herbal and dietary supplements for safety or effectiveness before they hit store shelves.Last year’s global menopause market was nearly $18 billion, Grand View Research reports, with dietary supplements carving out a 94% share.As a practitioner of integrative medicine, Bell is hardly antisupplement. But be sure to discuss any supplements you’re considering with your doctor, she said. Even supplements marketed as natural may be toxic depending on your lifestyle, medical history and other medications you’re on.Hot flash treatments in particular have a high placebo effect rate in clinical trials, about 30%-35%, Minkin estimated. For that reason, she said she has no problem with patients who claim that home remedies such as evening primrose oil provide symptom relief.“As long as it’s something that I know is pretty safe,” Minkin said. “[If] she says it’s arsenic, I’d say, ‘Probably not a good idea.’ So I have to look at the potential toxicity of what she might be using.”Minkin is thrilled that menopause, once taboo, is not only making headlines but also being celebrated — an “estrogen festival,” she called it. However, she warned that some wellness companies are crashing the party, hoping to make money off women in midlife.“For 20 years, we could attribute nothing to menopause; it was a dirty topic,” Minkin said. “But at this point, I think we’re leaning toward saying that everything is perimenopause, because perimenopause is very amorphous.”“You can’t test for it, really.”Lindsey LeakeLindsey Leake is an award-winning health journalist and contributor to NBC News. She holds an MA in Science Writing from Johns Hopkins University, an MA in Journalism and Digital Storytelling from American University and a BA from Princeton University.
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Oct. 19, 2025, 8:45 AM EDTBy Kaitlin SullivanCovid vaccines may come with a tantalizing benefit that has nothing to do with the virus they’re designed to protect against: boosting the immune system to better fight tumors during cancer treatment.That’s according to new results presented Sunday in Berlin at the European Society for Medical Oncology conference. The research is still in the earlier stages — it has yet to be tested in a Phase 3 clinical trial — but experts say it shows promise.“I am cautiously optimistic,” said Stephanie Dougan, an associate professor of cancer immunology and virology at the Dana-Farber Cancer Institute, who was not involved with the work. “There is a scientific logic to why this could work.”Researchers found that among cancer patients getting immunotherapy, those who got an mRNA Covid vaccine within 100 days before starting their treatment lived longer.Only about 20% of cancer patients who get immunotherapy — which harnesses a person’s immune system to fight cancer cells — respond to the treatment. Finding a way to boost the effectiveness of immunotherapy drugs has been a feat researchers have been exploring for years, with little success.Typically, the immune-stimulating tactics employed in the past have either done too little to activate the immune system or done too much, triggering an overactive response that can damage the body. There’s a chance that mRNA Covid vaccines could exist in a Goldilocks zone.“Maybe we just needed something that was medium-strong, and this could potentially be it,” said Dougan, who emphasized the need for more research.That research will soon be underway: Dr. Adam Grippin, a senior resident in radiation oncology at the University of Texas MD Anderson Cancer Center who co-led the study, said his team is launching a Phase 3 clinical trial to confirm the initial results.In the research presented Sunday, Grippin and his co-authors looked back at survival rates among more than 1,000 people who had advanced non-small cell lung cancer and got immunotherapy as part of their treatment from 2019 through 2023. Of those, 180 people received an mRNA Covid vaccine within 100 days of starting treatment.The median survival for the group — when exactly half of those who underwent treatment are still alive — was nearly twice as long for those who were vaccinated compared to those who were not: about three years compared to just over 1.5 years.The researchers also compared the survival rates in a smaller group of patients getting immunotherapy for metastatic melanoma. Forty-three got an mRNA Covid vaccine; 167 did not. For those who didn’t get vaccinated, median survival was just over two years. Those who were vaccinated prior to treatment hadn’t yet reached their median survival point more than three years into follow-up.In further experiments in mice, the researchers got an answer they believe matches the way the vaccines work in humans.“It superdrives the immune system against tumors,” Grippin said.Creating a beaconVaccines that use mRNA are already a promising area of cancer research. Scientists have developed personalized mRNA cancer vaccines that are tailored to fight a person’s unique tumor, as well as ones that target genes that are commonly found in certain types of cancer, including pancreatic. (These developments come as the Trump administration has canceled half a billion dollars in funding for mRNA vaccine research for infectious diseases.)If Grippin’s later trial confirms the results of the early research, it could represent the next frontier for research on mRNA vaccines and cancer.Immunotherapy drugs work by boosting the immune system’s ability to fight cancer, often by enhancing the power of immune cells called T cells that attack invaders, or by making tumors easier for T cells to find.The mouse portion of the new research found that Covid mRNA vaccination appeared to make the immune system more attuned to recognizing tumors as a threat by stimulating dendritic cells, a type of white blood cell. When dendritic cells detect a threat, they turn on a sort of beacon that leads T cells to the perceived invader so they can attack. However, not everyone naturally has T cells that are capable of fighting tumors, which is why scientists believe immunotherapies only work in some of the cancer patients who take them. In these people, the immune system recognizes cancer cells as a threat, but their specific T cells are unable to stop the tumors from growing.“It’s just random chance whether you have those cells or you don’t,” said Jeff Coller, a professor of RNA biology and therapeutics at Johns Hopkins Medicine, who was not involved with the research.Getting an mRNA Covid vaccine doesn’t change whether a person has the specific T cells needed to fight their tumors, but it does appear to make it more likely that dendritic cells will detect a tumor as a problem and direct the T cells a person does have to the tumor. If those cells happen to be programmed to be able to kill tumor cells, having an mRNA vaccine that lights up the target before a person starts an immunotherapy can give their immune system a boost that helps the cancer therapy work better.Coller said one reason mRNA technology may be the best tool to elicit this response is because every cell in the body already contains mRNA.“We are really tapping into that natural process that your body already knows how to respond to,” he said. “You are using your body’s natural system to fight tumors.”Dougan said it’s possible that other factors could have accounted for better survival among people who were vaccinated prior to immunotherapy treatment. For example, a Covid infection may have weakened an unvaccinated person’s body and hindered their ability to fight off cancer cells. In the past, early studies like this one have shown promising results that didn’t pan out in later trials. “We have been misled by retrospective studies before,” she said.Grippin agreed the findings warrant a closer look. “This data is exciting, but all of these findings need to be validated in Phase 3 clinical trials to determine whether these vaccines should be used in our patients,” he said.Kaitlin SullivanKaitlin Sullivan is a contributor for NBCNews.com who has worked with NBC News Investigations. She reports on health, science and the environment and is a graduate of the Craig Newmark Graduate School of Journalism at City University of New York.
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Oct. 8, 2025, 9:14 AM EDT / Updated Oct. 8, 2025, 2:06 PM EDTBy Megan LebowitzPresident Donald Trump said in a post to Truth Social on Wednesday that Chicago Mayor Brandon Johnson and Illinois Gov. JB Pritzker “should be in jail” in an escalation of his conflict with the two Democratic officials.”Chicago Mayor should be in jail for failing to protect Ice Officers!” he said in the post. “Governor Pritzker also!”The president’s post comes a day after Texas National Guard troops arrived in Illinois, despite the Democrats’ fierce opposition. Trump has threatened for weeks to send troops to Chicago as part of a crime-fighting and immigration effort, and Democrats have slammed his push as overreach and a political stunt.Reached for comment, White House spokesperson Abigail Jackson said that “JB Pritzker and Brandon Johnson have blood on their hands” and accused them of having “stood idly by while innocent Americans fall victim to violent crime time and time again.”She argued that “instead of taking action to stop the crime, these Trump-Deranged buffoons would rather allow the violence to continue and attack the President for wanting to help make their city safe again.”The statement did not address NBC News’ questions about what crimes the president believes Johnson and Pritzker and whether the White House planned to try to have federal agents arrest them.Texas National Guard troops arrive outside Chicago02:11Pritzker responded to the president in a post to X, saying, “I will not back down.”“Trump is now calling for the arrest of elected representatives checking his power,” he said in the post. “What else is left on the path to full-blown authoritarianism?”Later, Pritzker told reporters that Trump is “a coward.””He likes to pretend to be a tough guy,” Pritzker said of the president. “Come and get me.”Reached for comment, Johnson said that “this is not the first time Trump has tried to have a Black man unjustly arrested.”“I’m not going anywhere,” he added.On Monday, Illinois sued in an attempt to prevent the White House from deploying federalized troops to Chicago. A judge scheduled a hearing on the case for Thursday and declined to sign a temporary restraining order, which would have blocked the administration as the case proceeds in court. The president’s comments come as protests across Immigration and Customs Enforcement have rippled across the country as the administration ramped up efforts to detain and deport migrants. The White House has previously argued that deploying the National Guard is necessary to “protect federal assets and personnel” and prevent “attacks on law enforcement.”Trump first deployed the National Guard to Los Angeles, over Gov. Gavin Newsom’s objections, after protests broke out in response to immigration raids. The president then ordered the National Guard to the streets of D.C., painting it as an effort to fight crime. The administration is also trying to send federalized National Guard troops from California to Portland, Oregon, but a judge granted a temporary restraining order this week to block the move as the case is considered in court. A Pentagon spokesperson had said that the troops would have worked to “support U.S. Immigration and Customs Enforcement and other federal personnel performing official duties, including the enforcement of federal law, and to protect federal property.” In Chicago, a frequent target of the president, Johnson signed an executive order on Monday in an effort to block immigration agents from using city property during their operations in Chicago. “We will not tolerate ICE agents violating our residents’ constitutional rights nor will we allow the federal government to disregard our local authority,” Johnson said in a press release marking the so-called “ICE Free Zone” executive order. Pritzker has emerged as a leading critic of the Trump administration as his state faces the president’s ire. Trump has compared Chicago to a “war zone,” and Pritzker said Sunday in an interview on CNN’s “State of the Union” that “they’re just making this up.””Then what do they do? They fire tear gas and smoke grenades, and they make it look like it’s a war zone,” Pritzker said on Sunday, appearing to refer to federal agents. “And they, you know, get people on the ground are, frankly, incited to want to do something about it, appropriately.”In recent days, Pritzker also said that he believed that Trump should be removed from office. “There is something genuinely wrong with this man, and the 25th Amendment ought to be invoked,” he said, referring to a process for removing the president from office.On Tuesday, Pritzker was asked during an event whether he believed he could be arrested. “I’m asking any of you to come visit me in the gulag in El Salvador,” Pritzker joked, referring to the prison where the Trump administration has deported some immigrants.House Speaker Mike Johnson did not say whether he believed Mayor Johnson and Pritzker should be jailed when asked by NBC News about Trump’s post. “Should they be in prison? Should the mayor of Chicago and the governor of Illinois be in prison?” Johnson responded. “I’m not the attorney general. I’m the Speaker of the House, and I’m trying to manage the chaos here. I’m not following the day-to-day on that.”Trump has repeatedly threatened legal action against some of his political opponents, including former FBI Director James Comey and New York Attorney General Letitia James. Last month, he urged Attorney General Pam Bondi in a post to Truth Social to not “delay any longer,” slamming his political opponents and writing, “JUSTICE MUST BE SERVED, NOW!!!”Comey was indicted days later and is set to be arraigned on Wednesday. Megan LebowitzMegan Lebowitz is a politics reporter for NBC News.Natasha Korecki and Julie Tsirkin contributed.
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